Bicalutamide (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blood in the urine
• Blurred vision
• Body aches or pain
• Congestion
• Cough or hoarseness
• Cough producing mucus
• Difficult or labored breathing
• Dizziness
• Dryness or soreness of the throat
• Fever or chills
• Headache
• Lower back or side pain
• Nervousness
• Painful or difficult urination
• Pounding in the ears
• Rapid weight gain
• Runny nose
• Shortness of breath
• Slow or fast heartbeat
• Sweating
• Tender, swollen glands in the neck
• Tightness in the chest
• Tingling of the hands or feet
• Trouble with swallowing
• Unusual weight gain or loss
• Voice changes
• Wheezing

• Abnormal growth filled with fluid or semisolid material
• Ankle, knee, or great toe joint pain
• Arm, back, or jaw pain
• Bleeding from the rectum or bloody stools
• Blindness
• Bloody nose
• Burning while urinating
• Burning, tingling, numbness, or pain in the hands, arms, feet, or legs
• Change in bowel habits
• Chest pain or discomfort
• Chest tightness or heaviness
• Chills
• Confusion
• Decrease in frequency of urination
• Decrease in urine volume
• Decreased vision
• Difficulty in passing urine (dribbling)
• Difficulty with swallowing or eating
• Dilated neck veins
• Dry mouth
• Fainting
• Fast or irregular heartbeat
• Fever
• Irregular breathing
• Joint stiffness or swelling
• Lightheadedness
• Loss of appetite
• Lump or swelling in the abdomen
• Nausea
• No blood pressure or pulse
• Noisy breathing
• Pain in the neck
• Pain or discomfort in the arms, jaw, back, or neck
• Painful blisters on trunk of the body
• Persistent non-healing sore
• Rapid, shallow breathing
• Reddish patch or irritated area
• Sensation of pins and needles
• Shiny bump
• Stabbing pain
• Stomach discomfort
• Stopping of heart
• Sunken eyes
• Swelling of the face, fingers, feet, or lower legs
• Thirst
• Tumor
• Unconsciousness
• Unexplained weight loss
• Unusual tiredness or weakness
• Vomiting
• Weight gain
• White, yellow or waxy scar-like area
• Wrinkled skin
• Yellow skin or eyes

• Hives or welts
• Itching
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Redness of the skin
• Skin rash

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Breast pain
• Constipation
• Decreased interest in sexual intercourse
• Diarrhea
• Difficulty with moving
• Dry skin
• Hair loss or thinning of the hair
• Heartburn
• Inability to have or keep an erection
• Indigestion
• Lack or loss of strength
• Leg cramps
• Loss in sexual ability, desire, drive, or performance
• Loss of strength or energy
• Muscle aching or cramping
• Muscle pain or weakness
• Nervousness
• Pain in the pelvis
• Pain or tenderness around the eyes and cheekbones
• Passing of gas
• Sleepiness or unusual drowsiness
• Stomach pain, fullness, or discomfort
• Stuffy or runny nose
• Swelling of the breasts or breast soreness in both females and males

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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