Tigecycline (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Cough or hoarseness
• Dizziness
• Fever or chills
• Headache
• Lower back or side pain
• Pain, warmth, or burning in the fingers, toes, and legs
• Painful or difficult urination
• Problems with vision or hearing

• Abdominal or stomach pain
• Accumulation of pus
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Bluish color
• Blurred vision
• Changes in skin color
• Confusion
• Convulsions
• Decreased urine
• Diarrhea
• Difficult or labored breathing
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Dry mouth
• Eye pain
• Fat in the stool
• Flushed, dry skin
• Fruit-like breath odor
• General feeling of illness
• Increased hunger
• Increased thirst
• Increased urination
• Irregular heartbeat
• Loss of appetite
• Mood changes
• Muscle pain or cramps
• Nausea or vomiting
• Nervousness
• Numbness or tingling in the hands, feet, or lips
• Pain
• Pale skin
• Pounding in the ears
• Rapid weight gain
• Shortness of breath
• Slow or fast heartbeat
• Sore throat
• Sweating
• Swollen, red, tender area of infection
• Tenderness
• Tightness in the chest
• Troubled breathing with exertion
• Unexplained weight loss
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusual weight gain or loss
• Wheezing

• Abdominal or stomach cramps
• Anxiety
• Black, tarry stools
• Bleeding gums
• Blood in the urine or stools
• Chest pain or discomfort
• Clay-colored stools
• Cold sweats
• Coma
• Cool, pale skin
• Dark urine
• Depression
• Difficulty in breathing
• Itching
• Muscle cramps in the hands, arms, feet, legs, or face
• Nightmares
• Pinpoint red spots on the skin
• Rash
• Shakiness
• Slurred speech
• Sores, ulcers, or white spots on the lips or in the mouth
• Swelling of the face, ankles, or hands
• Swollen glands
• Tremor
• Unpleasant breath odor
• Vomiting of blood
• Yellow eyes or skin

• Bloating
• Constipation
• Difficulty in swallowing
• Hives
• Indigestion
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Red streaks on the skin
• Swelling, tenderness, or pain at the injection site

• Acid or sour stomach
• Belching
• Heartburn
• Lack or loss of strength
• Sleeplessness
• Stomach discomfort, upset, or pain
• Trouble sleeping
• Unable to sleep

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• Change in taste or bad unusual or unpleasant (after) taste
• Increased clear or white vaginal discharge
• Itching of the vagina or genital area
• Pain during sexual intercourse
• Sleepiness or unusual drowsiness
• Thick, white vaginal discharge with no odor or with a mild odor
• Vaginal yeast infection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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