Valproate Sodium (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Black, tarry stools
• Bleeding gums
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blood in the urine or stools
• Chest pain
• Chills
• Confusion
• Cough or hoarseness
• Crying
• Delusions
• Dementia
• Depersonalization
• Diarrhea
• Dysphoria
• Euphoria
• Fever or chills
• General feeling of discomfort or illness
• Headache
• Joint pain
• Loss of appetite
• Lower back or side pain
• Mental depression
• Muscle aches and pains
• Nausea
• Painful or difficult urination
• Paranoia
• Pinpoint red spots on the skin
• Quick to react or overreact emotionally
• Rapid weight gain
• Rapidly changing moods
• Runny nose
• Shakiness and unsteady walk shakiness in the legs, arms, hands, or feet
• Shivering
• Sleepiness or unusual drowsiness
• Sore throat
• Sweating
• Tingling of the hands or feet
• Trembling or shaking of the hands or feet
• Trouble with sleeping
• Unsteadiness, trembling, or other problems with muscle control or coordination
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusual weight gain or loss
• Vomiting

• Bloody nose
• Blurred vision
• Bruising
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Change in walking and balance
• Clumsiness or unsteadiness
• Constipation
• Cough producing mucus
• Darkened urine
• Difficult or labored breathing
• Dizziness
• Excessive muscle tone
• Fast, pounding, or irregular heartbeat or pulse
• Fear or nervousness
• Increased need to urinate
• Indigestion
• Lack of coordination
• Large, flat, blue, or purplish patches in the skin
• Loss of bladder control
• Loss of strength or energy
• Mood or mental changes
• Muscle pain or weakness
• Muscle stiffness
• Muscle tension or tightness
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Passing urine more often
• Pounding in the ears
• Shortness of breath
• Small red or purple spots on the skin
• Sneezing
• Sore throat
• Stuffy nose
• Tightness in the chest
• Vomiting of blood or material that looks like coffee grounds
• Wheezing
• Yellow eyes or skin

• False or unusual sense of well-being
• Feeling faint, dizzy, or lightheadedness
• Feeling of warmth or heat
• Flushing or redness of the skin, especially on the face and neck

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Change in vision
• Continuing ringing or buzzing or other unexplained noise in the ears
• Double vision
• Hair loss or thinning of the hair
• Hearing loss
• Heartburn
• Impaired vision
• Indigestion
• Lack or loss of strength
• Loss of appetite
• Seeing double
• Sleeplessness
• Stomach discomfort, upset, or pain
• Unable to sleep
• Uncontrolled eye movements
• Weight gain
• Weight loss

• Absent, missed, or irregular menstrual periods
• Back pain
• Belching
• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• Change in taste or bad unusual or unpleasant (after) taste
• Difficulty having a bowel movement (stool)
• Difficulty with moving
• Dry skin
• Earache
• Excess air or gas in the stomach or intestines
• Full feeling
• Itching of the vagina or genital area
• Leg cramps
• Loss of memory
• Muscle pains or stiffness
• Pain
• Pain during sexual intercourse
• Pain or tenderness around the eyes and cheekbones
• Passing gas
• Problems with memory
• Rash
• Redness or swelling in the ear
• Stopping of menstrual bleeding
• Swollen joints
• Thick, white vaginal discharge with no odor or with a mild odor

• Body aches or pain
• Congestion
• Tender, swollen glands in the neck
• Trouble with swallowing
• Voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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