Amoxicillin and Clavulanate (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Hives or welts
• Itching
• Itching of the vagina or genital area
• Pain during sexual intercourse
• Redness of the skin
• Skin rash
• Thick, white vaginal discharge with no odor or with a mild odor

• Bloody or cloudy urine
• Fever
• Greatly decreased frequency of urination or amount of urine
• Seizures
• Swelling of the feet or lower legs

• Abdominal or stomach cramps or tenderness
• Back, leg, or stomach pains
• Black, hairy tongue
• Black, tarry stools
• Bleeding gums
• Blistering, peeling, or loosening of the skin
• Bloating
• Blood in the stools
• Bloody nose
• Chest pain
• Chills
• Clay-colored stools
• Cough or hoarseness
• Cracks in the skin
• Dark urine
• Diarrhea
• Diarrhea, watery and severe, which may also be bloody
• Difficulty with breathing
• Difficulty with moving
• Difficulty with swallowing
• Dizziness
• Fast heartbeat
• Fever with or without chills
• General body swelling
• General feeling of tiredness or weakness
• Headache
• Heavier menstrual periods
• Increased thirst
• Joint or muscle pain
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Light-colored stools
• Loss of appetite
• Loss of heat from the body
• Lower back or side pain
• Muscle stiffness
• Nausea or vomiting
• Pain
• Pain, swelling, or redness in the joints
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Rash
• Red skin lesions, often with a purple center
• Red, irritated eyes
• Red, swollen skin
• Scaly skin
• Shortness of breath
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Swollen glands
• Tightness in the chest
• Troubled breathing with exertion
• Unpleasant breath odor
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusual weight loss
• Upper right abdominal pain
• Vomiting of blood
• Wheezing
• White patches in the mouth or throat or on the tongue
• White patches with diaper rash
• Yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Abdominal or stomach pain
• Bloody or cloudy urine
• Diarrhea
• Fever
• Greatly decreased frequency of urination or amount of urine
• Pain or burning while urinating
• Skin rash
• Sleepiness
• Swelling of the feet or lower legs
• Vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Anxiety
• Dry mouth
• Hyperventilation
• Irregular heartbeats
• Irritability
• Nervousness
• Restlessness
• Shaking
• Sleeplessness
• Tooth discoloration
• Trouble sitting still
• Trouble with sleeping
• Unable to sleep

• Burning feeling in the chest or stomach
• Indigestion
• Redness, swelling, or soreness of the tongue
• Stomach upset
• Swelling or inflammation of the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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