Piperacillin and Tazobactam (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Diarrhea

• Bladder pain
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Bloody or cloudy urine
• Blurred vision
• Breakdown of the skin
• Burning upper abdominal or stomach pain
• Changes in skin color
• Chest pain
• Confusion
• Decrease in the amount of urine
• Difficult or labored breathing
• Difficult, burning, or painful urination
• Dizziness
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Enlarged abdomen or stomach
• Fever
• Frequent urge to urinate
• Headache
• Increased sweating
• Inflammation or swelling at the injection site
• Irritation and redness of the skin
• Loss of appetite
• Loss of bladder control
• Lower back or side pain
• Nausea
• Nervousness
• No blood pressure or pulse
• Noisy, rattling breathing pain
• Pain, tenderness, or swelling of the foot or leg
• Pain, warmth, or burning in the fingers, toes, and legs
• Pounding in the ears
• Problems with vision or hearing
• Rapid weight gain
• Severe pain in the chest
• Shortness of breath
• Skin rash
• Slow or fast heartbeat
• Stopping of heart
• Sudden onset of severe breathing difficulty
• Sweating
• Tightness in the chest
• Tingling of the hands or feet
• Troubled breathing at rest
• Unconsciousness
• Unusual tiredness or weakness
• Unusual weight gain or loss
• Vomiting
• Weight gain
• Wheezing

• Abdominal or stomach cramps, pain, or tenderness
• Agitation
• Anxiety
• Bleeding gums
• Bloody nose
• Bloody, black, or tarry stools
• Blue lips and fingernails
• Bone pain
• Bruising
• Canker sores
• Chest congestion
• Chills
• Cold sweats
• Coma
• Convulsions
• Cool, pale skin
• Cough
• Coughing or spitting up blood
• Coughing that sometimes produces a pink frothy sputum
• Decrease in the amount of urine
• Decrease in the frequency of urination
• Decrease in urine volume
• Deep or fast breathing with dizziness
• Depression
• Diarrhea, watery and severe, which may also be bloody
• Difficult, fast, or noisy breathing, sometimes with wheezing
• Difficulty in passing urine (dribbling)
• Difficulty with swallowing
• Drowsiness
• Dry mouth
• Excessive muscle tone
• Extra heart beat
• Eye pain
• Fainting or loss of consciousness
• Fast, pounding, or irregular heartbeat or pulse
• Flushed, dry skin
• Fruit-like breath odor
• General feeling of illness
• High blood pressure
• Hives
• Hostility
• Inability to speak
• Increase in heart rate
• Increased clear or white vaginal discharge
• Increased hunger
• Increased thirst
• Increased urination
• Irritability
• Itching
• Itching of the vagina or genital area
• Large, flat, blue, or purplish patches in the skin
• Lethargy
• Lightheadedness
• Muscle pain or cramps
• Muscle stiffness or twitching
• Muscle tension or tightness
• Nightmares
• No blood pressure or pulse
• Numbness or tingling in the hands, feet, or lips
• Pain during sexual intercourse
• Pale skin
• Pinpoint red or purple spots on the skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Rapid breathing
• Rapid heartbeat
• Restlessness
• Seizures
• Severe constipation
• Severe or sudden headache
• Severe vomiting
• Shakiness in the legs, arms, hands, or feet
• Slurred speech
• Sore throat
• Sores, ulcers, or white spots on the lips, tongue, or inside the mouth
• Sudden shortness of breath or troubled breathing
• Sunken eyes
• Swelling of the face, ankles, feet, or lower legs
• Swelling of the eyes, eyelids, or hands
• Swelling or inflammation of the mouth
• Swollen glands
• Temporary blindness
• Thick, white vaginal discharge with no odor or with a mild odor
• Thirst
• Total body jerking
• Troubled breathing
• Troubled breathing with exertion
• Unconsciousness
• Unexplained weight loss
• Unusual bleeding or bruising
• Unusual weight loss
• Weakness
• Weakness in the arm or leg on one side of the body, sudden and severe
• Wrinkled skin

• Back or leg pain
• Blistering, peeling, or loosening of the skin
• Clay-colored stools
• Dark urine
• Fever with or without chills
• General body swelling
• General feeling of tiredness or weakness
• Greatly decreased frequency of urination or amount of urine
• High fever
• Joint or muscle pain
• Nosebleeds
• Red, irritated eyes
• Red skin lesions, often with a purple center
• Unexplained bleeding or bruising
• Unpleasant breath odor
• Vomiting of blood
• Weight gain
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Difficulty having a bowel movement (stool)
• Sleeplessness
• Trouble sleeping
• Unable to sleep

• Acid or sour stomach
• Belching
• Breakdown of skin
• Cracks in the skin at the corners of mouth
• Heartburn
• Hiccup
• Indigestion
• Irritation and redness of the skin
• Runny nose
• Sneezing
• Soreness or redness around the fingernails and toenails
• Stomach discomfort, upset, or pain
• Stuffy nose
• White patches in the mouth or on the tongue

• Body aches or pain
• Burning feeling in the chest or stomach
• Change in color vision
• Change in taste or bad unusual or unpleasant (after) taste
• Congestion
• Continuing ringing or buzzing or other unexplained noise in the ears
• Decreased awareness or responsiveness
• Difficulty seeing at night
• Difficulty with moving
• Double vision
• Dry skin
• Excess air or gas in the stomach or intestines
• Feeling of constant movement of self or surroundings
• Feeling of warmth
• Feeling unusually cold
• Full feeling
• Hearing loss
• Heartburn
• Increased sensitivity of the eyes to sunlight
• Itching or pain of the genital area
• Lack or loss of strength
• Passing gas
• Redness of the face, neck, arms, and occasionally, upper chest
• Redness, swelling, or soreness of the tongue
• Seeing double
• Sensation of spinning
• Severe sleepiness
• Shivering
• Sleepiness or unusual drowsiness
• Stomach upset
• Tenderness in stomach area
• Voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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