Paliperidone (Intramuscular Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Anxiety
• Bladder pain
• Bloody or cloudy urine
• Body aches or pain
• Chills
• Cough
• Difficult, burning, or painful urination
• Difficulty with breathing
• Difficulty with swallowing
• Dry mouth
• Ear congestion
• Fever
• Frequent urge to urinate
• Headache
• Hyperventilation
• Inability to sit still
• Irregular heartbeats
• Irritability
• Loss of balance control
• Loss of voice
• Lower back or side pain
• Mask-like face
• Nasal congestion
• Need to keep moving
• Nervousness
• Restlessness
• Runny nose
• Shaking
• Shortness of breath
• Shuffling walk
• Slowed movements
• Slurred speech
• Sneezing
• Sore throat
• Stiffness of the arms and legs
• Tic-like (jerky) movements of the head, face, mouth, and neck
• Trembling and shaking of the fingers and hands
• Trouble with sleeping
• Twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
• Unusual tiredness or weakness

• Blurred vision
• Difficulty with speaking
• Dizziness
• Drooling
• Headache
• Inability to move the eyes
• Increase in body movements
• Increased blinking or spasms of the eyelid
• Loss of balance control
• Muscle trembling, jerking, or stiffness
• Pounding in the ears
• Restlessness
• Slow or fast heartbeat
• Sticking out of the tongue
• Stiffness of the limbs
• Tremor
• Trouble with breathing, speaking, or swallowing
• Twisting movements of the body
• Uncontrolled movements, especially of the face, neck, and back
• Uncontrolled twisting movements of the neck, trunk, arms, or legs
• Unusual facial expressions

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• Sleeplessness
• Unable to sleep

• Back pain
• Constipation
• Diarrhea
• Difficulty with moving
• Dry mouth
• Increased weight
• Joint pain
• Lack or loss of strength
• Muscle aching or cramping
• Muscle pains or stiffness
• Nausea
• Nightmares
• Pain in the arms or legs
• Stuffy or runny nose
• Swollen joints
• Tearing of the skin
• Toothache
• Upper abdominal or stomach pain
• Vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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