Pazopanib (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach pain or tenderness
• Black, tarry stools
• Bleeding gums
• Blood in the urine or stools
• Blurred vision
• Chest pain
• Chills
• Clay colored stools
• Cloudy urine
• Constipation
• Cough
• Coughing up blood
• Dark urine
• Decreased appetite
• Depressed mood
• Difficulty with breathing or swallowing
• Dizziness
• Dry skin and hair
• Feeling cold
• Fever
• Hair loss
• Headache
• Hoarseness or husky voice
• Increased menstrual flow or vaginal bleeding
• Itching
• Loss of appetite
• Lower back or side pain
• Muscle cramps and stiffness
• Nausea and vomiting
• Nervousness
• Nosebleeds
• Painful or difficult urination
• Pale skin
• Paralysis
• Pinpoint red spots on the skin
• Pounding in the ears
• Prolonged bleeding from cuts
• Red or black, tarry stools
• Red or dark brown urine
• Redness, swelling, or pain of the skin
• Scaling of the skin on the hands and feet
• Shortness of breath
• Skin rash
• Slow or fast heartbeat
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Swelling of the feet or lower legs
• Swollen glands
• Tingling of the hands and feet
• Ulceration of the skin
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Weight gain
• Yellow eyes or skin

• Bleeding from rectum or bloody stools
• Bloody nose
• Chest discomfort
• Confusion
• Fainting
• Irregular heartbeat
• Irregular or slow heart rate
• Numbness or tingling in the face, arms, or legs
• Pain or discomfort in the shoulders, arms, jaw, back, or neck
• Sweating
• Swelling or puffiness of the face
• Trouble speaking, thinking, or walking

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Change in hair color
• Change in taste
• Decreased weight
• Diarrhea
• Hair loss
• Lack or loss of strength
• Loss of taste
• Thinning of the hair
• Weight loss

• Acid or sour stomach
• Belching
• Heartburn
• Indigestion
• Stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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