Buprenorphine (Injection Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Drowsiness
• Relaxed and calm
• Sleepiness

• Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the site
• Bluish color of the fingernails, lips, skin, palms, or nail beds
• Blurred vision
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain or discomfort
• Confusion
• Difficult or labored breathing
• Feeling, seeing, or hearing things that are not there
• Feeling that others are watching you or controlling your behavior
• Feeling that others can hear your thoughts
• Headache
• Severe mood or mental changes
• Shortness of breath
• Slurred speech
• Tightness of the chest
• Unusual behavior
• Wheezing

• Anxiety
• Cough
• Diarrhea
• Difficulty breathing
• Dry mouth
• Hyperventilation
• Irregular heartbeats
• Irritability
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Loss of muscle coordination
• Nervousness
• Noisy breathing
• Restlessness
• Seizures
• Shaking
• Trouble sleeping
• Wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Nausea

• Constricted, pinpoint, or small pupils (black part of the eye)
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Extremely shallow or slow breathing
• Sweating
• Vomiting

• Burning, dry, or itching eyes
• Chills
• Continuing ringing or buzzing or other unexplained noise in the ears
• Decrease in frequency of urination
• Decrease in urine volume
• Depression
• Difficulty in passing urine (dribbling)
• Discharge, excessive tearing
• Dreaming
• Dry mouth
• False or unusual sense of well-being
• Fast, pounding, or irregular heartbeat or pulse
• Feeling of warmth
• Hearing loss
• Itching of the skin
• Painful urination
• Pounding in the ears
• Redness of the face, neck, arms and occasionally, upper chest
• Redness, pain, or swelling of the eye, eyelid, or inner lining of eyelid
• Unusual tiredness or weakness

• Acid or sour stomach
• Belching
• Bloated
• Bluish lips or skin
• Change in vision
• Excess air or gas in the stomach or intestines
• Feeling of unreality
• Full feeling
• General feeling of discomfort or illness
• Heartburn
• Hives or welts
• Impaired vision
• Indigestion
• Loss of appetite
• Not breathing
• Paleness of the skin
• Passing gas
• Redness of the skin
• Sense of detachment from self or body
• Skin rash
• Stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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