Nalbuphine (Injection Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Chest pain or discomfort
• Difficult or labored breathing
• Difficulty swallowing
• Fainting
• False beliefs that cannot be changed by facts
• Fast, pounding, or irregular heartbeat or pulse
• Puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
• Redness of the face, neck, arms and occasionally, upper chest
• Seeing, hearing, or feeling things that are not there
• Sense of detachment from self or body
• Shortness of breath
• Slow or irregular heartbeat
• Wheezing

• Blue lips and fingernails
• Convulsions
• Coughing that sometimes produces a pink frothy sputum
• Decrease in consciousness
• Difficult, fast, or noisy breathing, sometimes with wheezing
• Fear or nervousness
• Fever
• Hyperventilation
• Increased sweating
• Loss of bladder control
• Muscle spasm or jerking of all extremities
• Pale skin
• Shakiness in legs, arms, hands, or feet
• Sleepiness or unusual drowsiness
• Stomach pain
• Sudden loss of consciousness
• Swelling in legs and ankles
• Trembling or shaking of hands or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Dizziness or lightheadedness
• Drowsiness
• Feeling of constant movement of self or surroundings
• Nausea
• Relaxed and calm
• Sensation of spinning
• Sleepiness
• Sweaty, clammy skin
• Vomiting

• Dry mouth
• Headache

• Acid or sour stomach
• Aggressive or angry
• Belching
• Blurred vision
• Burning
• Changes in speech
• Confusion
• Cough
• Discouragement
• Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• Dysphoria
• Excessive crying
• False or unusual sense of well-being
• Feeling of heaviness
• Feeling of warmth
• Feeling sad or empty
• Floating feeling
• Frequent strong or increased urge to urinate
• Headache
• Heartburn
• Hives or welts
• Indigestion
• Irritability
• Itching of skin
• Lack of appetite
• Loss of interest or pleasure
• Nervousness
• Numbness
• Pounding in the ears
• Restlessness
• Skin rash
• Slow or fast heartbeat
• Stomach discomfort, upset, or pain
• Tiredness
• Trouble concentrating
• Trouble sleeping
• Tingling feeling of unreality
• Unusual tiredness or weakness

• Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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