Oxycodone and Aspirin (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal pain, cramping, or tenderness
• Agitation
• Bleeding gums
• Bloating
• Blood in the urine or stools
• Bloody, black, or tarry stools
• Blue lips, fingernails, or skin
• Blurred vision
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Change in consciousness or confusion
• Chest pain or discomfort
• Chills
• Clay-colored stools
• Constipation
• Convulsions
• Coughing or vomiting blood
• Dark-colored urine
• Decrease in urine volume or frequency
• Decreased appetite
• Depression
• Difficult, fast, noisy breathing, sometimes with wheezing
• Difficulty in passing urine (dribbling)
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Drowsiness
• Dry mouth
• Fainting
• Fast, slow, irregular, pounding, or racing heartbeat or pulse
• Feeling of hostility or irritability
• Feeling of warmth
• Feeling that something terrible will happen
• Fever
• Headache, sudden, severe
• Heartburn
• Hives or itching
• Increased menstrual flow or vaginal bleeding
• Increased sweating
• Indigestion
• Irregular, fast, slow, or shallow breathing
• Large, flat, blue or purplish patches in the skin
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Loss of consciousness
• Low body temperature
• Muscle cramping, weakness, or tremors
• Muscle pain or stiffness
• Nausea or vomiting
• Nosebleeds
• Numbness or tingling in the hands, feet, or lips
• Painful or difficult urination
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Pale skin
• Pinpoint red or purple spots on the skin
• Prolonged bleeding from cuts
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Red or black, tarry stools or dark urine
• Restlessness
• Shivering
• Shortness of breath
• Skin rash
• Sleepiness
• Sunken eyes
• Sweating
• Swelling of face, ankles, hands, feet, or lower legs
• Thirst
• Tightness in the chest
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting of material that looks like coffee grounds, severe and continuing
• Weak or feeble pulse
• Weakness or heaviness of the legs
• Weight gain
• Wheezing
• Wrinkled skin
• Yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Continuing ringing or buzzing or other unexplained noise in the ears
• Decreased awareness or responsiveness
• Diarrhea
• Drowsiness
• Enlarged pupils
• Extremely high fever or body temperature
• Fast, weak heartbeat
• Hearing loss
• Increase in heart rate
• Restlessness
• Severe sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Relaxed and calm feeling
• Sleepiness

• Belching
• Bloated, full feeling
• Blurred or loss of vision
• Change in color perception
• Cold sweats
• Constricted, pinpoint, or small pupils (black part of the eye)
• Cool, pale skin
• Double vision
• Excess air or gas in the stomach
• False or unusual sense of well-being
• Flushed, dry skin
• Fruit-like breath odor
• Halos around lights
• Increased hunger or thirst
• Increased urination
• Lack or loss of strength
• Night blindness
• Nightmares
• Overbright appearance of lights
• Red eyes
• Redness of the skin
• Seeing, hearing, or feeling things that are not there
• Shakiness
• Sleepiness or unusual drowsiness
• Slurred speech
• Trouble sleeping
• Tunnel vision
• Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
• Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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