Oxycodone (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Chills
• Cold sweats
• Confusion
• Difficult or labored breathing
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Fever
• Shortness of breath
• Tightness in the chest
• Twitching
• Wheezing

• Abdominal or stomach pain
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blood in the urine
• Burning while urinating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain
• Convulsions
• Cough
• Decrease in the frequency of urination
• Decrease in urine volume
• Decreased urine output
• Difficult or painful urination
• Difficulty in passing urine (dribbling)
• Difficulty with swallowing
• Dizziness
• Dry mouth
• Fainting
• Fast or irregular heartbeat
• Fast, irregular, pounding, or racing heartbeat or pulse
• Feeling of warmth or heat
• Flushing or redness of the skin, especially on the face and neck
• Frequent urination
• Headache
• Hives
• Increase in heart rate
• Increased thirst
• Increased volume of pale, dilute urine
• Itching
• Lightheadedness
• Muscle pain or cramps
• Nausea or vomiting
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Rapid breathing
• Rapid weight gain
• Severe constipation
• Severe vomiting
• Shakiness in the legs, arms, hands, or feet
• Skin rash
• Sunken eyes
• Sweating
• Swelling or puffiness of the face
• Swollen, painful, or tender lymph glands in the neck, armpit, or groin
• Thirst
• Tingling of the hands or feet
• Trembling or shaking of the hands or feet
• Unusual tiredness or weakness
• Unusual weight gain or loss
• Wrinkled skin

• Blurred vision
• Choking
• Clay-colored stools
• Cold, clammy skin
• Dark urine
• Diarrhea
• Fast, weak pulse
• Gagging
• Irregular, fast, slow, or shallow breathing
• Loss of appetite
• Low blood pressure or pulse
• Pale or blue lips, fingernails, or skin
• Trouble with swallowing
• Unconsciousness
• Unpleasant breath odor
• Very slow breathing
• Very slow heartbeat
• Yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

• Change in consciousness
• Chest pain or discomfort
• Constricted, pinpoint, or small pupils (black part of the eye)
• Decreased awareness or responsiveness
• Extreme drowsiness
• Loss of consciousness
• No muscle tone or movement
• Severe sleepiness
• Slow or irregular heartbeat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Difficulty having a bowel movement (stool)
• Drowsiness
• Lack or loss of strength
• Relaxed and calm feeling
• Sleepiness or unusual drowsiness

• Abnormal dreams
• Acid or sour stomach
• Anxiety
• Belching
• Burning feeling in the chest or stomach
• False or unusual sense of well-being
• Heartburn
• Hiccups
• Indigestion
• Nervousness
• Sleeplessness
• Stomach discomfort, upset, or pain
• Tenderness in the stomach area
• Trouble with sleeping
• Unable to sleep
• Weight loss

• Absent, missed, or irregular menstrual periods
• Bad, unusual or unpleasant (after) taste
• Bloated or full feeling
• Body aches or pain
• Change in taste
• Change in walking and balance
• Changes in vision
• Clumsiness or unsteadiness
• Congestion
• Continuing ringing or buzzing or other unexplained noise in the ears
• Cracks in the skin
• Crying
• Decreased interest in sexual intercourse
• Dental caries or tooth decay
• Depersonalization
• Depression
• Difficulty with speaking
• Dry skin
• Dryness or soreness of the throat
• Dysphoria
• Excess air or gas in the stomach or intestines
• Excessive muscle tone
• Feeling of constant movement of self or surroundings
• Feeling of unreality
• General feeling of discomfort or illness
• Headache, severe and throbbing
• Hearing loss
• Hives or welts
• Hoarseness
• Hyperventilation
• Inability to have or keep an erection
• Increase in body movements
• Increased appetite
• Increased cough
• Irritability
• Loss in sexual ability, desire, drive, or performance
• Loss of heat from the body
• Loss of memory
• Loss of strength or energy
• Mental depression
• Muscle pain or weakness
• Muscle stiffness
• Muscle tension or tightness
• Neck pain
• Paranoia
• Passing of gas
• Problems with memory
• Quick to react or overreact emotionally
• Rapidly changing moods
• Red, swollen skin
• Restlessness
• Runny nose
• Scaly skin
• Sensation of spinning
• Sense of detachment from self or body
• Severe sleepiness
• Stomach pain, fullness, or discomfort
• Stopping of menstrual bleeding
• Swelling or inflammation of the mouth
• Tender, swollen glands in the neck
• Unusual weak feeling
• Voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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