Morphine (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach pain
• Blurred vision
• Bulging soft spot on the head of an infant
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Change in the ability to see colors, especially blue or yellow
• Chest pain or discomfort
• Confusion
• Cough
• Decreased urination
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Fainting
• Fast, pounding, or irregular heartbeat or pulse
• Headache
• Hives, itching, or skin rash
• Increased sweating
• Loss of appetite
• Nausea or vomiting
• Nervousness
• Pounding in the ears
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Severe constipation
• Severe vomiting
• Shakiness in the legs, arms, hands, or feet
• Shortness of breath
• Slow heartbeat
• Sweating or chills
• Wheezing

• Black, tarry stools
• Cold, clammy skin
• Feeling of warmth or heat
• Flushing or redness of the skin, especially on the face and neck
• Irregular, fast or slow, or shallow breathing
• Lightheadedness
• Loss of consciousness
• Low blood pressure or pulse
• Nervousness
• Painful urination
• Pale or blue lips, fingernails, or skin
• Pale skin
• Pinpoint red spots on the skin
• Pounding in the ears
• Shakiness and unsteady walk
• Unsteadiness, trembling, or other problems with muscle control or coordination
• Unusual bleeding or bruising
• Very slow heartbeat

Get emergency help immediately if any of the following symptoms of overdose occur:

• Constricted, pinpoint, or small pupils (black part of the eye)
• Decreased awareness or responsiveness
• Extreme drowsiness
• Fever
• Increased blood pressure
• Increased thirst
• Lower back or side pain
• Muscle cramps or spasms
• Muscle pain or stiffness
• No muscle tone or movement
• Severe sleepiness
• Swelling of the face, fingers, or lower legs
• Weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Cramps
• Difficulty having a bowel movement (stool)
• Drowsiness
• False or unusual sense of well-being
• Relaxed and calm feeling
• Sleepiness or unusual drowsiness
• Weight loss

• Absent, missed, or irregular menstrual periods
• Agitation
• Bad, unusual, or unpleasant (after) taste
• Change in vision
• Depression
• Dry mouth
• Face is warm or hot to touch
• Floating feeling
• Halos around lights
• Heartburn or indigestion
• Loss in sexual ability, desire, drive, or performance
• Muscle stiffness or tightness
• Night blindness
• Overbright appearance of lights
• Problems with muscle control
• Redness of the skin
• Skin rash
• Sleeplessness
• Stomach discomfort, upset, or pain
• Trouble sleeping
• Unable to sleep
• Uncontrolled eye movements

• Abnormal dreams
• Change in walking and balance
• Change or problem with discharge of semen
• Clumsiness or unsteadiness
• Confusion as to time, place, or person
• Delusions
• Dementia
• Feeling of constant movement of self or surroundings
• General feeling of discomfort or illness
• Holding false beliefs that cannot be changed by fact
• Problems with memory
• Seeing, hearing, or feeling things that are not there
• Sensation of spinning
• Unusual excitement, nervousness, or restlessness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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