Naproxen and Esomeprazole (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Burning feeling in the chest or stomach
• Indigestion
• Loss of appetite
• Nausea
• Stomach bloating, cramping, or pain
• Tenderness in the stomach area
• Upper abdominal or stomach pain
• Upset stomach
• Vomiting
• Weight loss

• Abdominal or stomach discomfort
• Black, tarry stools
• Bladder pain
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Bloody or cloudy urine
• Bloody stools
• Chest pain
• Difficult, burning, or painful urination
• Difficulty with moving
• Difficulty with swallowing
• Frequent urge to urinate
• Full or bloated feeling
• Heartburn
• Lower back or side pain
• Muscle pain or stiffness
• Pain in the joints
• Pain or burning in the throat
• Pressure in the stomach
• Rapid weight gain
• Sores, ulcers, or white spots on the lips or tongue or inside the mouth
• Swelling of the abdominal or stomach area
• Tingling of the hands or feet
• Unusual weight gain or loss
• Vomiting of blood or material that looks like coffee grounds

• Drowsiness
• Mood or mental changes
• Muscle spasms (tetany) or twitching
• Seizures
• Trembling
• Unusual tiredness or weakness
• Vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Diarrhea

• Body aches or pain
• Change in taste
• Chills
• Cough
• Cough producing mucus
• Difficulty having a bowel movement (stool)
• Difficulty with breathing
• Ear congestion
• Excess air or gas in the stomach or intestines
• Fever
• Headache
• Loss of taste
• Loss of voice
• Pain or tenderness around the eyes and cheekbones
• Passing gas
• Shortness of breath or troubled breathing
• Sneezing
• Sore throat
• Stuffy or runny nose
• Tightness of the chest or wheezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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