Ondansetron (Oral Route, Oromucosal Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Confusion
• Dizziness
• Fast heartbeat
• Fever
• Headache
• Shortness of breath
• Weakness

• Decrease in the frequency of urination
• Decrease in urine volume
• Difficulty with passing urine (dribbling)
• Painful urination

• Arm, back, or jaw pain
• Chest pain or discomfort
• Chest tightness or heaviness
• Convulsions
• Cough
• Decreased urine
• Difficulty with breathing
• Difficulty with swallowing
• Dry mouth
• Fast, pounding, or irregular heartbeat or pulse
• Hives
• Increased thirst
• Itching
• Loss of appetite
• Loss of bladder control
• Loss of consciousness
• Mood changes
• Muscle pain or cramps
• Nausea or vomiting
• Noisy breathing
• Numbness or tingling in the hands, feet, or lips
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Skin rash
• Sweating
• Tightness in the chest
• Total body jerking
• Unusual tiredness or weakness
• Wheezing

• Blurred vision
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Fixed position of the eye
• Heart stops
• Hoarseness
• Inability to move the eyes
• Increased blinking or spasms of the eyelid
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• No breathing
• No pulse or blood pressure
• Noisy breathing
• Pounding heartbeat
• Slow or irregular breathing
• Sticking out of the tongue
• Sweating
• Trouble with breathing, speaking, or swallowing
• Unconscious
• Uncontrolled twisting movements of the neck, trunk, arms, or legs
• Unusual facial expressions

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Anxiety
• Difficulty having a bowel movement (stool)
• Dry mouth
• General feeling of discomfort or illness
• Hyperventilation
• Irritability
• Restlessness
• Shaking
• Trouble sleeping

• Difficulty with speaking
• Drooling
• Loss of balance control
• Muscle trembling, jerking, or stiffness
• Shuffling walk
• Stiffness of the limbs
• Twisting movements of the body
• Uncontrolled movements, especially of the face, neck, and back

• Feeling of warmth
• Hiccups
• Hives or welts
• Redness of the face, neck, arms, and occasionally, upper chest
• Redness of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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