Etoposide (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Black, tarry stools
• Bleeding gums
• Blood in the urine or stools
• Chest pain
• Chills
• Cough
• Fever
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Shortness of breath
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Swollen glands
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Unusual tiredness or weakness

• Blurred vision
• Confusion
• Cough
• Difficulty with swallowing
• Dizziness
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Fast heartbeat
• Feeling of warmth
• Headache
• Hives
• Itching
• Nervousness
• Numbness or tingling in the fingers or toes
• Pounding in the ears
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Redness of the face, neck, arms, and occasionally, upper chest
• Skin rash
• Slow or fast heartbeat
• Sweating
• Tightness in the chest
• Wheezing

• Bone pain

• Abdominal or stomach pain, severe
• Blistering, peeling, or loosening of the skin
• Cough or hoarseness
• Dark urine
• Diarrhea
• Difficult breathing
• Drowsiness
• Joint or muscle pain
• Loss of appetite
• Lower back or side pain
• Muscle tremors
• Nausea or vomiting
• Rapid, deep breathing
• Red, irritated eyes
• Red skin lesions, often with a purple center
• Restlessness
• Seizures
• Stomach cramps
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Hair loss or thinning of the hair
• Swelling or inflammation of the mouth
• Weight loss

• Bad, unusual, or unpleasant (after) taste
• Change in taste
• Constipation
• Cracked lips
• General feeling of discomfort or illness
• Heartburn
• Lack or loss of strength
• Pain or burning in the throat
• Sleepiness or unusual drowsiness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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