Pegloticase (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Chest pain or discomfort
• Cough
• Difficult or labored breathing
• Difficulty with swallowing
• Dizziness
• Facial swelling
• Fast heartbeat
• Fever or chills
• Flushing or redness of the skin
• Gout flare
• Headache
• Hives or welts
• Itching
• Nausea or vomiting
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Redness of the skin
• Shortness of breath
• Skin rash
• Tightness in the chest
• Unusual tiredness or weakness
• Unusually warm skin
• Wheezing

• Decreased urine output
• Dilated neck veins
• Extreme fatigue
• Irregular breathing
• Irregular heartbeat
• Swelling of the face, fingers, feet, or lower legs
• Troubled breathing
• Weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Bruise
• Contusion
• Difficulty having a bowel movement (stool)
• Large, flat, blue, or purplish patches in the skin
• Muscle aches
• Sore throat
• Stuffy or runny nose

• Vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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