Hylan Polymers A and B (Injection Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Difficulty with moving
• Fluid build up around the knee
• Muscle pain or stiffness
• Pain and stiffness in the joints

• Bleeding after defecation
• Bluish color
• Changes in skin color
• Fainting
• Fast, pounding, or irregular heartbeat or pulse
• Pain or aching in the lower legs
• Swelling of the ankles, feet, or legs
• Tenderness
• Uncomfortable swelling around the anus
• Warmth or swelling of the joints

• Redness in the joints
• Trouble with walking

• Black, tarry stools
• Bleeding gums
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blood in the urine or stools
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chills
• Difficulty with breathing
• Feeling of warmth
• General feeling of discomfort or illness
• Muscle cramps
• Pinpoint red spots on the skin
• Rapid weight gain
• Redness of the face, neck, arms, and occasionally, upper chest
• Shortness of breath
• Tingling of the hands or feet
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusual weight gain or loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Itching of the skin
• Rash
• Sprain in the lower back

• Pain at the injection site

• Dizziness
• Headache
• Nausea
• Raised red swellings on the skin, lips, tongue, or in the throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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