Medroxyprogesterone (Intramuscular Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
  • Absent, missed, or irregular menstrual periods
  • Menstrual changes
  • Stopping of menstrual bleeding
Less common
  • Breast pain
  • Cramps
  • Heavy bleeding
  • Increased clear or white vaginal discharge
  • Itching of the vagina or genital area
  • Pain during sexual intercourse
  • Swelling
  • Thick, white vaginal discharge with no odor or with a mild odor
Incidence not known
  • Abdominal or stomach pain
  • Anxiety
  • Black, tarry stools
  • Blood in the stools
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • Changes in skin color
  • Chest pain
  • Chills
  • Clay-colored stools
  • Clear or bloody discharge from the nipple
  • Cough
  • Dark urine
  • Decrease in height
  • Difficult or labored breathing
  • Difficulty with breathing
  • Difficulty with swallowing
  • Dimpling of the breast skin
  • Dizziness or lightheadedness
  • Dull ache or feeling of pressure or heaviness in the legs
  • Fainting
  • Fast, pounding, or irregular heartbeat or pulse
  • Fever
  • Headache
  • Hives
  • Increased thirst
  • Inverted nipple
  • Itching
  • Itching skin near damaged veins
  • Loss of appetite
  • Lump in the breast or under the arm
  • Nausea
  • No sensation in the legs
  • Noisy breathing
  • Pain in the back, ribs, arms, or legs
  • Pain, redness, tenderness, or swelling of the arm, foot, or leg
  • Pale skin
  • Persistent crusting or scaling of the nipple
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Rash
  • Redness or swelling of the breast
  • Shortness of breath
  • Skin rash
  • Sore on the skin of the breast that does not heal
  • Sudden shortness of breath or troubled breathing
  • Swollen feet and ankles
  • Tightness in the chest
  • Troubled breathing with exertion
  • Unable to move the legs
  • Unpleasant breath odor
  • Unusual bruising or bleeding
  • Unusual tiredness or weakness
  • Vomiting of blood
  • Wheezing
  • Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach discomfort
  • Decreased interest in sexual intercourse
  • Inability to have or keep an erection
  • Increased weight
  • Loss in sexual ability, desire, drive, or performance
  • Nervousness
Less common
  • Backache
  • Blemishes on the skin
  • Bloating
  • Depression
  • Difficulty with moving
  • Feeling of warmth
  • Hair loss or thinning of the hair
  • Lack or loss of strength
  • Leg cramps
  • Muscle pain or stiffness
  • Pain in the joints
  • Pimples
  • Redness of the face, neck, arms, and occasionally, upper chest
  • Sleeplessness
  • Sudden sweating
  • Trouble sleeping
  • Unable to sleep
Incidence not known
  • Brown, blotchy spots on the exposed skin
  • Changes in appetite
  • Diarrhea
  • Drowsiness
  • Dry skin
  • Hoarseness
  • Increased hair growth, especially on the face
  • Increased in sexual ability, desire, drive, or performance
  • Increased interest in sexual intercourse
  • Increased sweating and body odor
  • Indigestion
  • Loss of appetite
  • Pain at the injection site
  • Passing of gas
  • Patchy brown or dark brown discoloration of the skin
  • Stomach pain, fullness, or discomfort
  • Swelling of the armpits
  • Unexpected or excess milk flow from breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Precautions
DR603381 Portions of this document last updated: Sept. 1, 2012

Source: Drug Information provided by: Micromedex

Copyright © 2013 Thomson Healthcare Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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