Febuxostat (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach fullness or pain
• Arm, back, or jaw pain
• Black, tarry stools
• Bloody nose
• Blurred vision
• Chest pain or discomfort
• Chills
• Cloudy urine
• Confusion
• Cough
• Dark urine
• Decreased frequency or amount of urine
• Diarrhea
• Difficult or labored breathing
• Difficulty with moving
• Dizziness
• Dry mouth
• Fainting
• Fast, irregular, pounding, or racing heartbeat or pulse
• Feeling of fullness
• Fever
• Gaseous abdominal or stomach pain
• General tiredness and weakness
• Headache
• Heavier menstrual periods
• Inability to speak
• Increase in heart rate
• Increased thirst
• Itching
• Joint pain, stiffness, or swelling
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Lightheadedness
• Loss of appetite
• Loss of bladder control
• Muscle aching or cramping
• Nausea and vomiting
• Nervousness
• Pain, swelling, or redness in the joints
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Pounding in the ears
• Rapid breathing
• Rash
• Redness of the skin
• Right upper abdominal or stomach pain and fullness
• Runny nose
• Seizures
• Severe or sudden headache
• Shivering
• Shortness of breath
• Slow or fast heartbeat
• Slurred speech
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Sunken eyes
• Sweating
• Swelling
• Temporary blindness
• Thirst
• Tightness in the chest
• Trouble sleeping
• Troubled breathing or swallowing
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting of blood or material that looks like coffee grounds
• Weakness in the arm or leg on one side of the body, sudden and severe
• Weight gain
• Wheezing
• Wrinkled skin
• Yellow eyes and skin

• Blistering, peeling, or loosening of the skin
• Diarrhea
• Difficulty with swallowing
• Hives
• Muscle cramps or spasms
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Red skin lesions, often with a purple center
• Red, irritated eyes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Anxiety
• Bad, unusual, or unpleasant (after) taste
• Blistering, crusting, irritation, itching, or reddening of the skin
• Body aches or pain
• Breast pain
• Bruising
• Burning feeling in the chest or stomach
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Change in taste
• Changes in hair color
• Constipation
• Continuing ringing or buzzing or other unexplained noise in the ears
• Cough producing mucus
• Cracked, dry, or scaly skin
• Decrease in smell
• Decreased interest in sexual intercourse
• Depression
• Ear congestion
• Excess air or gas in the stomach or intestines
• Feeling of constant movement of self or surroundings
• Fruit-like breath odor
• Gum pain
• Hair loss or thinning of the hair
• Hearing loss
• Heartburn
• Hyperventilation
• Inability to have or keep an erection
• Inability to move the arms and legs
• Increased or decreased appetite
• Increased sensitivity of the skin to sunlight
• Increased sweating
• Increased urination
• Irritability
• Large, flat, blue, or purplish patches in the skin
• Loss in sexual ability, desire, drive, or performance
• Loss of appetite
• Loss of consciousness
• Loss of voice
• Muscle or bone pain or stiffness
• Muscle spasm, tightness, or weakness
• Muscle twitching
• Nasal congestion
• Painful blisters on the trunk of the body
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Sensation of spinning
• Severe or continuing stomach pain
• Severe sunburn
• Shakiness in the legs, arms, hands, or feet
• Skin rash, encrusted, scaly, and oozing
• Sleepiness or unusual drowsiness
• Small red or purple spots on the skin
• Sneezing
• Stomach discomfort, upset, or pain
• Sudden numbness and weakness in the arms and legs
• Sweating
• Swelling of the breasts or breast soreness in both females and males
• Throat irritation
• Trembling or shaking of the hands or feet
• Trouble sleeping
• Unexplained weight loss
• Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
• Weight loss

• Aggressive thoughts
• Delusions
• Hallucinations

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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