Ipilimumab (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Bloody, black, or tarry stools
• Diarrhea
• Fever
• Heartburn
• Indigestion
• Itching skin
• Nausea
• Rash
• Severe stomach pain, cramping, or burning
• Unusual tiredness or weakness
• Vomiting
• Vomiting of material that looks like coffee grounds, severe and continuing
• Watery or bloody diarrhea

• Abdominal or stomach tenderness
• Blistering, crusting, irritation, itching, or reddening of the skin
• Bloody or cloudy urine
• Blurred vision or other changes in vision
• Burning, dry, or itching eyes
• Burning, tingling, numbness or pain in the hands, arms, feet, or legs
• Chest pain
• Chills
• Clay-colored stools
• Cough
• Cracked, dry, or scaly skin
• Dark urine
• Darkening of the skin
• Decreased appetite
• Decreased frequency or amount of urine
• Difficulty with breathing, chewing, swallowing, or talking
• Dizziness
• Double vision
• Drooping eyelids
• Drowsiness
• Eye discharge or excessive tearing
• Eye pain or sensitivity to light
• Fainting
• Headache, possibly severe
• Hives or welts
• Loss of appetite
• Mental depression
• Muscle weakness
• Pain, itching, burning, swelling, bleeding, or a lump under the skin where the needle was placed
• Painful or difficult urination
• Redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
• Sensation of pins and needles
• Severe tiredness
• Shortness of breath
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Stabbing pain
• Swelling of the face, feet, or lower legs
• Swollen glands
• Trouble breathing
• Unusual bleeding or bruising
• Unusual weight gain
• Yellow eyes or skin

• Anxiety
• Bloating
• Blue or pale skin
• Chest pain, possibly moving to the left arm, neck, or shoulder
• Confusion
• Constipation
• Difficulty with moving
• Fast heartbeat
• General feeling of discomfort or illness
• Increased blood pressure
• Increased thirst
• Lower back or side pain
• Muscle pain or stiffness
• Muscle weakness
• Pain or burning in the throat
• Pain, swelling, or redness in the joints
• Pains in the stomach or side, possibly radiating to the back
• Skin irritation or rash, including rash that looks like psoriasis
• Sores, welting, or blisters on the skin
• Stiff neck or back

• Back, leg, or stomach pains
• Bleeding gums
• General body swelling
• Inability to move the arms and legs
• Nosebleeds
• Throbbing pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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