Vandetanib (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach cramps or pain
• Bleeding gums
• Blurred vision
• Body aches or pain
• Chest pain
• Cloudy urine
• Confusion
• Convulsions
• Cough
• Coughing up blood
• Difficulty with breathing or swallowing
• Dizziness
• Ear congestion
• Fainting
• Fever or chills
• Headache
• Increased menstrual flow or vaginal bleeding
• Irregular heartbeat recurrent
• Loss of voice
• Muscle cramps in the hands, arms, feet, legs, or face
• Nervousness
• Nosebleeds
• Numbness and tingling around the mouth, fingertips, or feet
• Paralysis
• Pounding in the ears
• Prolonged bleeding from cuts
• Red or black, tarry stools
• Red or dark brown urine
• Slow or fast heartbeat
• Sneezing
• Sore throat
• Stuffy or runny nose
• Tenderness
• Tightness in the chest
• Tremor
• Troubled breathing
• Unusual tiredness or weakness (severe)
• Watery or bloody diarrhea

• Blue lips, fingernails, or skin
• Chest pain or discomfort
• Dilated neck veins
• Extreme fatigue
• Foreign substance into the lungs
• Infection from breathing
• Irregular breathing
• Irregular heartbeat
• Irregular, fast or slow, or shallow breathing
• Lightheadedness
• No breathing
• Swelling of the face, fingers, feet, or lower legs
• Weight gain

• Bloating
• Constipation
• Darkened urine
• Decreased urine output
• Indigestion
• Loss of appetite
• Nausea
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Blemishes on the skin
• Blindness
• Blistering, crusting, irritation, itching, or reddening of the skin
• Change in taste
• Cracked, dry, or scaly skin
• Cracks in the skin
• Decreased appetite
• Decreased vision
• Decreased weight
• Depression
• Discoloration of the fingernails or toenails
• Dry mouth
• Dry skin
• Hair loss or thinning of the hair
• Heartburn
• Increased sensitivity of the skin to sunlight
• Itching skin
• Lack or loss of strength
• Loosening of the fingernails
• Loss of heat from the body
• Loss of taste
• Muscle aches or spasms
• Pimples
• Rash with flat lesions or small raised lesions on the skin
• Red, swollen skin
• Redness or other discoloration of the skin
• Redness or soreness around the fingernails
• Severe sunburn
• Stomach discomfort or upset
• Swelling
• Trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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