Ezogabine (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Decrease in the frequency of urination
• Decrease in the urine volume
• Difficulty with passing urine (dribbling)
• Painful urination
• Shakiness in the legs, arms, hands, or feet

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blood in the urine
• Burning while urinating
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Difficult urination
• General feeling of discomfort or illness
• Muscle twitching or jerking
• Rapid weight gain
• Rhythmic movement of the muscles
• Tingling of the hands or feet
• Trouble with urinating
• Unusual tiredness or weakness
• Unusual weight gain or loss

• Agitation
• Back pain
• Black, tarry stools
• Bleeding gums
• Blurred vision
• Change in consciousness
• Chest pain
• Chills
• Cloudy urine
• Confusion
• Cough
• Difficult or labored breathing
• Dizziness
• Drowsiness
• Fainting
• Fever
• Headache
• Irritability
• Loss of consciousness
• Pain in the lower back or side
• Pinpoint red spots on the skin
• Shortness of breath
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Stiff neck
• Swollen glands
• Tightness in the chest
• Unusual bleeding or bruising
• Vomiting
• Wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Being forgetful
• Clumsiness or unsteadiness
• Dizziness or lightheadedness
• Double vision
• Feeling of constant movement of self or surroundings
• Seeing double
• Sensation of spinning
• Sleepiness or unusual drowsiness

• Absence of or decrease in the body movement
• Acid or sour stomach
• Belching
• Changes in patterns and rhythms of speech
• Confusion about identity, place, and time
• Cough
• Diarrhea
• Difficulty having a bowel movement (stool)
• Difficulty with swallowing
• Dry mouth
• Fear or nervousness
• Feeling that others are watching you or controlling your behavior
• Feeling that others can hear your thoughts
• Feeling, seeing, or hearing things that are not there
• Heartburn
• Increased appetite
• Increased sweating
• Indigestion
• Joint pain
• Lack or loss of strength
• Loss of appetite
• Loss of memory
• Muscle aches and pains
• Problems with memory problems with speech or speaking
• Runny nose
• Severe mood or mental changes
• Shivering
• Slurred speech
• Stomach discomfort, upset, or pain
• Sweating
• Trouble with sleeping
• Trouble with speaking
• Trouble with walking
• Unusual behavior
• Weight gain

• False or unusual sense of well-being
• Hair loss or thinning of the hair
• Muscle spasms
• Rash
• Uncontrolled eye movements

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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