Crizotinib (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Black, tarry stools
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Body aches or pain
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain or discomfort
• Cough or hoarseness
• Difficult or labored breathing
• Ear congestion
• Fever or chills
• Headache
• Increased sensitivity to pain or touch
• Lightheadedness, dizziness, or fainting
• Loss of voice
• Lower back or side pain
• Nasal congestion
• Nerve pain
• Painful or difficult urination
• Pale skin
• Rapid weight gain
• Runny or stuffy nose
• Shortness of breath
• Slow or irregular heartbeat
• Sneezing
• Sore throat
• Tightness in the chest
• Tingling in the hands and feet
• Ulcers, sores, or white spots in the mouth
• Unsteadiness or awkwardness
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusual weight gain or loss
• Weakness in the arms, hands, legs, or feet
• Wheezing

• Bleeding gums
• Blood in the urine or stools
• Pinpoint red spots on the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abdominal or stomach discomfort, pain, or tenderness
• Acid or sour stomach
• Back pain
• Belching
• Blurred vision
• Change in color vision
• Change in taste
• Chapped, red, or swollen lips
• Decrease or change in vision
• Decreased appetite
• Diarrhea
• Difficulty having a bowel movement (stool)
• Difficulty seeing at night
• Difficulty with moving
• Difficulty with swallowing
• Double vision
• Heartburn
• Increased sensitivity of the eyes to sunlight
• Indigestion
• Loss of taste
• Muscle pain or stiffness
• Nausea
• Pain in the joints
• Pain or burning in the throat
• Pain or discomfort in the chest, upper stomach, or throat
• Problems with balance
• Rash
• Redness, swelling, or soreness of the tongue
• Scaling, redness, burning, pain, or other signs of inflammation of the lips
• Seeing double
• Seeing flashes or sparks of light
• Sleeplessness
• Sores, ulcers, or white spots on the lips or tongue or inside the mouth
• Swelling or inflammation of the mouth
• Trouble with sleeping
• Unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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