Tacrolimus (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Abdominal or stomach pain
• Abnormal dreams
• Agitation
• Anxiety
• Chills
• Confusion
• Convulsions (seizures)
• Diarrhea
• Dizziness
• Fever and sore throat
• Flu-like symptoms
• Frequent urination
• Headache
• Infection
• Itching
• Loss of appetite
• Loss of energy or weakness
• Mental depression
• Muscle trembling or twitching
• Nausea
• Nervousness
• Pale skin
• Seeing or hearing things that are not there
• Shortness of breath
• Skin rash
• Swelling of the feet or lower legs
• Tingling
• Trembling and shaking of the hands
• Trouble with sleeping
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Vomiting

• Blurred vision
• Chest pain
• Increased sensitivity to pain
• Muscle cramps
• Numbness or pain in the legs
• Ringing in the ears
• Sweating

• Enlarged heart
• Flushing of the face or neck
• General feeling of discomfort or illness
• Weight loss
• Wheezing

• Black, tarry stools
• Blistering, peeling, or loosening of the skin
• Bloating
• Bloody urine
• Blurred vision
• Constipation
• Cough
• Drowsiness
• Fainting
• Fast, slow, or irregular heartbeat
• Heartburn
• Increased blood pressure
• Increased thirst
• Indigestion
• Joint or muscle pain
• Lightheadedness
• Loss of appetite
• Lower back or side pain
• Nausea
• Pinpoint red spots on skin
• Pounding or rapid pulse
• Red, irritated eyes
• Red skin lesions, often with a purple center
• Shortness of breath
• Skin sores
• Stomach pain
• Troubled breathing
• Ulcers or white spots in mouth or on lips
• Weakness
• Weight gain
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• Belching
• Difficulty with moving
• Lack or loss of strength
• Muscle pain or stiffness
• Unable to sleep

• Body aches or pain
• Burning or stinging of the skin
• Cracks in the skin
• Crying
• Delusions
• Dementia
• Depersonalization
• Dysphoria
• Euphoria
• Excessive muscle tone
• Feeling of constant movement of self or surroundings
• Feeling that others are watching you or controlling your behavior
• Feeling that others can hear your thoughts
• Increased sensitivity of the skin to sunlight
• Large, flat, blue or purplish patches in the skin
• Loss of strength or energy
• Muscle tension or tightness
• Painful blisters on the trunk of the body
• Painful cold sores or blisters on the lips, nose, eyes, or genitals
• Paranoia
• Quick to react or overreact emotionally
• Rapidly changing moods
• Redness or other discoloration of the skin
• Restlessness
• Scaly skin
• Sensation of spinning
• Severe mood or mental changes
• Severe sunburn
• Sleepiness or unusual drowsiness
• Sore mouth or tongue
• Sores on the skin
• Swelling or inflammation of the mouth
• Tender, swollen glands in the neck
• Unusual behavior
• White patches in the mouth, tongue, or throat

• Change in color vision
• Decreased weight
• Difficulty seeing at night
• Feeling hot and cold
• Hearing loss
• Sudden sweating

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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