Estradiol (Transdermal Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach cramps or pain
• Acid or sour stomach
• Anxiety
• Backache
• Belching
• Blistering, peeling, or loosening of the skin
• Bloating
• Blurred vision
• Breast tenderness, enlargement, pain, or discharge
• Change in vaginal discharge
• Changes in skin color
• Changes in vision
• Chest pain or discomfort
• Chills
• Clay-colored stools
• Clear or bloody discharge from the nipple
• Confusion
• Constipation
• Convulsions
• Cough
• Darkening of the urine
• Diarrhea
• Difficulty with breathing
• Difficulty with swallowing
• Dimpling of the breast skin
• Dizziness or lightheadedness
• Double vision
• Fainting
• Fast heartbeat
• Fever
• Fluid-filled skin blisters
• Full or bloated feeling or pressure in the stomach
• Headache
• Headache, severe and throbbing
• Heartburn
• Hives
• Indigestion
• Inverted nipple
• Irregular heartbeats
• Itching of the skin
• Itching of the vagina or genital area
• Joint or muscle pain
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Light-colored stools
• Loss of appetite
• Loss of bladder control
• Lump in the breast or under the arm
• Migraine headache
• Mood or mental changes
• Muscle cramps in the hands, arms, feet, legs, or face
• Muscle spasm or jerking of all extremities
• Nausea
• Noisy breathing
• Numbness and tingling around the mouth, fingertips, or feet
• Pain during sexual intercourse
• Pain in the ankles or knees
• Pain or discomfort in the arms, jaw, back, or neck
• Pain or feeling of pressure in the pelvis
• Pain, redness, or swelling in the arm, foot, or leg
• Painful, red lumps under the skin, mostly on the legs
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Persistent crusting or scaling of the nipple
• Poor insight and judgment
• Problems with memory or speech
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Rash
• Red, irritated eyes
• Redness or swelling of the breast
• Sensitivity to the sun
• Shortness of breath
• Skin thinness
• Sore on the skin of the breast that does not heal
• Sore throat
• Sores, ulcers, or white spots in the mouth or on the lips
• Stomach discomfort, upset, or pain
• Sudden loss of consciousness
• Sudden shortness of breath or troubled breathing
• Sweating
• Swelling
• Swelling of the abdominal or stomach area
• Thick, white vaginal discharge with no odor or with a mild odor
• Tightness in the chest
• Tremor
• Trouble recognizing objects
• Trouble thinking and planning
• Trouble walking
• Unexpected or excess milk flow from the breasts
• Unpleasant breath odor
• Unusual tiredness or weakness
• Unusually heavy or unexpected menstrual bleeding
• Vaginal bleeding or spotting
• Vomiting
• Vomiting of blood
• Wheezing
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Back pain
• Difficulty with moving
• Muscle aches
• Muscle pain or stiffness
• Stuffy or runny nose

• Decreased interest in sexual intercourse
• Heavy bleeding
• Hives or welts
• Inability to have or keep an erection
• Increased hair growth, especially on the face
• Increased in sexual ability, desire, drive, or performance
• Increased interest in sexual intercourse
• Irritability
• Leg cramps
• Loss in sexual ability, desire, drive, or performance
• Loss of scalp hair
• Mental depression
• Mood disturbances
• Patchy brown or dark brown discoloration of the skin
• Redness of the skin
• Twitching, uncontrolled movements of the tongue, lips, face, arms, or legs
• Weight changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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