Bupivacaine Liposome (Injection Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blurred vision
• Confusion
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Fast, pounding, or irregular heartbeat or pulse
• Fever
• Pale skin
• Rapid weight gain
• Sweating
• Tingling of the hands or feet
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusual weight gain or loss

• Bleeding from the anus
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain or discomfort
• Fainting
• Lightheadedness, dizziness, or fainting
• Painful defecation
• Shortness of breath
• Slow or irregular heartbeat
• Swelling at the surgical site

• Chills
• Decrease in the frequency of urination
• Decrease in the urine volume
• Difficult or troubled breathing
• Difficulty in passing urine (dribbling)
• Extra heart beat
• Headache
• Hives
• Hoarseness
• Irregular, fast or slow, or shallow breathing
• Irritation
• Itching
• Joint pain, stiffness, or swelling
• Nervousness
• Not breathing
• Painful urination
• Pale or blue lips, fingernails, or skin
• Pounding in the ears
• Rash
• Redness of the skin
• Shakiness in the legs, arms, hands, or feet
• Shortness of breath
• Swelling at the incision site
• Tightness in the chest
• Troubled breathing or swallowing
• Weakness
• Wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Back pain
• Muscle spasm
• Nausea
• Sleepiness or unusual drowsiness
• Sleeplessness
• Trouble sleeping
• Unable to sleep
• Vomiting

• Decreased appetite
• Itching in the genital or other skin areas
• Scaling
• Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

• Agitation
• Cold sweats
• Hives or welts
• Increased sweating
• Muscle weakness
• Pain in the neck
• Paleness of the skin
• Restlessness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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