Asparaginase Erwinia Chrysanthemi (Intramuscular Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Cough
• Difficulty with swallowing
• Dizziness
• Fast heartbeat
• Fever
• Hives or welts
• Hoarseness
• Irritation
• Itching
• Joint pain, stiffness, or swelling
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Rash
• Redness of the skin
• Shortness of breath
• Swelling of the eyelids, face, lips, hands, or feet
• Tightness in the chest
• Troubled breathing or swallowing
• Unusual tiredness or weakness
• Wheezing

• Abdominal or stomach pain
• Bloating
• Blurred vision
• Chills
• Constipation
• Darkened urine
• Dry mouth
• Flushed, dry skin
• Fruit-like breath odor
• Increased hunger
• Increased thirst
• Increased urination
• Indigestion
• Loss of appetite
• Nausea
• Pains in the chest, groin, or legs, especially calves of the legs
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Seizures
• Severe headaches of sudden onset
• Sudden loss of coordination
• Sudden onset of shortness of breath for no apparent reason
• Sudden onset of slurred speech
• Sudden vision changes
• Sweating
• Unexplained weight loss
• Vomiting
• Yellow eyes or skin

• Blood in the urine or stools
• Bruising
• Confusion
• Coughing or vomiting blood
• Headache
• Numbness or tingling in the face, arms, or legs
• Persistent bleeding or oozing from puncture sites, mouth, or nose
• Red streaks on the skin
• Swelling, tenderness, or pain at the injection site
• Trouble speaking, thinking, or walking

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Diarrhea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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