Linagliptin and Metformin (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Anxiety
• Blurred vision
• Chills
• Cold sweats
• Coma
• Confusion
• Cool, pale skin
• Depression
• Dizziness
• Fast heartbeat
• Headache
• Increased hunger
• Nausea
• Nightmares
• Seizures
• Shakiness
• Slurred speech
• Unusual tiredness or weakness

• Bloating
• Constipation
• Darkened urine
• Fainting spells
• Fever
• Indigestion
• Irregular heartbeat
• Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Loss of appetite
• Pains in the stomach, side, or abdomen, possibly radiating to the back
• Vomiting
• Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Diarrhea
• Excess air or gas in the stomach or intestines
• Full feeling
• Heartburn
• Lack or loss of strength
• Muscle aches
• Passing gas
• Sore throat
• Stuffy or runny nose

• Cough
• Decreased appetite
• Difficulty with moving
• Flaking and falling off of the skin
• Hives or welts
• Itching
• Joint pain
• Muscle aching or cramping
• Muscle pains or stiffness
• Redness of the skin
• Skin rash
• Swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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