Axitinib (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bleeding gums
• Bloody nose
• Blurred vision
• Cloudy urine
• Confusion
• Constipation
• Coughing up blood
• Decreased urination
• Depressed mood
• Difficult or labored breathing
• Difficulty with swallowing
• Dizziness
• Dry mouth
• Dry skin and hair
• Fainting
• Feeling cold
• Hair loss
• Headache
• Hoarseness or husky voice
• Increase in heart rate
• Increased menstrual flow or vaginal bleeding
• Lightheadedness
• Muscle cramps and stiffness
• Nervousness
• Nosebleeds
• Paralysis
• Pounding in the ears
• Prolonged bleeding from cuts
• Rapid breathing
• Red or black, tarry stools
• Red or dark brown urine
• Redness, swelling, or pain of the skin
• Scaling of the skin on the hands and feet
• Shortness of breath
• Slow or fast heartbeat
• Sunken eyes
• Thirst
• Tightness in the chest
• Tingling of the hands and feet
• Ulceration of the skin
• Unusual tiredness or weakness
• Weight gain
• Wheezing
• Wrinkled skin

• Abdominal or stomach pain
• Anxiety
• Bleeding after defecation
• Bleeding from the gums or nose
• Bleeding from the rectum
• Bloody, black or tarry stools
• Change in vision
• Chest pain or discomfort
• Extreme drowsiness
• Eye pain
• Heartburn
• Inability to speak
• Indigestion
• Nausea
• Numbness or tingling in the face, arms, hands, or legs
• Pain or discomfort in the arms, jaw, back, or neck
• Pain, redness, or swelling in the arm or leg
• Pains in the chest, groin, or legs, especially calves of the legs
• Pale skin
• Ringing in the ears
• Seizures
• Sensitivity to heat
• Severe abdominal or stomach pain, cramping, or burning
• Severe headaches of sudden onset
• Slurred speech
• Sudden loss of coordination
• Sudden onset of shortness of breath for no apparent reason
• Sudden onset of slurred speech
• Sudden shortness of breath or troubled breathing
• Sudden vision changes
• Sweating
• Temporary blindness
• Trouble breathing
• Trouble sleeping
• Trouble speaking, thinking, or walking
• Troubled breathing with exertion
• Uncomfortable swelling around the anus
• Unusual bleeding or bruising
• Vomiting
• Vomiting of material that looks like coffee grounds, severe and continuing
• Weakness in the arm or leg on one side of the body, sudden and severe
• Weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Belching
• Change in taste
• Cough
• Cracked lips
• Decreased appetite
• Diarrhea
• Difficulty with moving
• Itching skin
• Joint pain
• Lack or loss of strength
• Loss of taste
• Muscle aches or pain
• Pain in the arms or legs
• Rash
• Sore throat
• Sores, ulcers, or white spots on the lips, tongue, or inside the mouth
• Stomach discomfort or upset
• Swelling or inflammation of the mouth
• Swollen joints
• Upper abdominal or stomach pain
• Voice changes

• Continuing ringing or buzzing or other unexplained noise in the ears
• Flushing or redness of the skin
• Hearing loss
• Thinning of the hair
• Unusually warm skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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