Carfilzomib (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Agitation
• Black, tarry stools
• Bleeding gums
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blood in the urine or stools
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Chest pain
• Confusion
• Cough or hoarseness
• Decreased urine output
• Depression
• Difficult or labored breathing
• Difficulty with moving
• Dizziness
• Drowsiness
• Fast or irregular heartbeat
• Hostility
• Irregular heartbeat
• Irritability
• Lower back or side pain
• Muscle spasms (tetany) or twitching
• Nausea or vomiting
• Numbness or tingling in the hands, feet, or lips
• Painful or difficult urination
• Pale skin
• Pinpoint red spots on the skin
• Seizures
• Shortness of breath
• Stupor
• Swelling of the face, ankles, or hands
• Tightness in the chest
• Tingling of the hands or feet
• Trembling
• Troubled breathing with exertion
• Ulcers, sores, or white spots in the mouth
• Unsteadiness or awkwardness
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Unusual weight gain or loss
• Wheezing

• Chills
• Fever
• Muscle pain or cramps
• Pain in the joints
• Painful blisters on the trunk of the body
• Weakness in the arms, hands, legs, or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abdominal or stomach pain
• Back pain
• Blurred vision
• Body aches or pain
• Bone pain
• Constipation
• Diarrhea
• Dry mouth
• Ear congestion
• Flushed, dry skin
• Fruit-like breath odor
• Headache
• Increased hunger
• Increased thirst
• Increased urination
• Loss of appetite
• Loss of voice
• Metallic taste
• Muscle weakness
• Pain in the arms or legs
• Runny nose
• Sneezing
• Sore throat
• Sweating
• Trouble sleeping
• Weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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