Aflibercept (Intravenous Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Anxiety
• Black, tarry stools
• Bladder pain
• Bleeding gums
• Blood in the urine or stools
• Bloody nose
• Blurred vision
• Chest pain
• Confusion
• Cough or hoarseness
• Decreased urination
• Difficult, burning, or painful urination
• Dizziness or lightheadedness
• Dry mouth
• Excessive thirst
• Fainting
• Fever or chills
• Frequent urge to urinate
• Headache
• Hoarseness
• Lower back or side pain
• Nervousness
• Pain or swelling around the rectum
• Pale skin
• Pinpoint red spots on the skin
• Pounding in the ears
• Slow or fast heartbeat
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Sudden shortness of breath or troubled breathing
• Sunken eyes
• Swollen glands
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Voice changes
• Wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Abdominal or stomach pain
• Decreased appetite
• Diarrhea
• Lack or loss of strength
• Redness, swelling, or pain of the skin
• Runny nose
• Scaling of the skin on the hands and feet
• Swelling or inflammation of the mouth
• Tingling of the hands and feet
• Ulceration of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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