Enzalutamide (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Back pain
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blood in urine
• Blurred vision
• Chest pain
• Cough
• Cough with mucus
• Difficulty breathing
• Dizziness
• Fever or chills
• Headache
• Loss of bladder control
• Loss of bowel control
• Nervousness
• No sensation in the legs
• Painful or difficult urination
• Pounding in the ears
• Rapid weight gain
• Shortness of breath
• Slow or fast heartbeat
• Sneezing
• Sore throat
• Tightness in the chest
• Tingling of the hands or feet
• Unable to move legs
• Unusual weight gain or loss
• Wheezing

• Confusion or excitement
• Fainting
• Falling
• Lightheadedness
• Loss of memory
• Mental depression or anxiety
• Nightmares or unusually vivid dreams
• Problems with memory or attention span
• Rapid, shallow breathing
• Trouble performing routine tasks

• Seizures

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Body aches or pain
• Bone pain
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Diarrhea
• Difficulty in moving
• Dry throat
• Ear congestion
• Feeling of constant movement of self or surroundings
• Feeling of warmth
• Hoarseness
• Joint pain
• Lack or loss of strength
• Loss of voice
• Muscle pain, stiffness, or weakness
• Nervousness
• Pain or tenderness around the eyes and cheekbones
• Redness of the face, neck, arms and occasionally, upper chest
• Sensation of spinning
• Stuffy or runny nose
• Tender, swollen glands in the neck
• Trouble with swallowing
• Trouble sleeping
• Unusual tiredness or weakness
• Voice changes

• Bloody nose
• Dry skin
• Frequent urination
• Itching skin
• Pale-colored urine

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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