Methadone (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Black, tarry stools
• Bleeding gums
• Blood in the urine or stools
• Blurred vision
• Bulging soft spot on the head of an infant
• Change in the ability to see colors, especially blue or yellow
• Changes in skin color
• Chest discomfort or pain
• Confusion
• Convulsions
• Cough
• Coughing that sometimes produces a pink frothy sputum
• Decreased urine output
• Difficult or troubled breathing
• Difficult, fast, noisy breathing, sometimes with wheezing
• Difficulty swallowing
• Dilated neck veins
• Dizziness
• Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• Dry mouth
• Extreme fatigue
• Fainting
• Fast, slow, or irregular heartbeat
• Headache
• Hives
• Increased sweating
• Increased thirst
• Irregular heartbeat recurrent
• Irregular, fast or slow, or shallow breathing
• Itching
• Loss of appetite
• Muscle pain or cramps
• Nausea or vomiting
• Numbness or tingling in the hands, feet, or lips
• Pain
• Pale or blue lips, fingernails, or skin
• Pinpoint red spots on the skin
• Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• Seizures
• Skin rash
• Sweating
• Swelling of the face, fingers, feet, or lower legs
• Tenderness
• Trouble in urinating
• Trouble sleeping
• Unusual bleeding or bruising
• Unusual tiredness or weakness
• Weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Absent, missed, or irregular menstrual periods
• Anxiety
• Blurred or loss of vision
• Confusion about identity, place, and time
• Constipation
• Decreased interest in sexual intercourse
• Disturbed color perception
• Double vision
• False or unusual sense of well-being
• Halos around lights
• Inability to have or keep an erection
• Irritability
• Lack or loss of strength
• Loss in sexual ability, desire, drive, or performance
• Night blindness
• Overbright appearance of lights
• Redness, swelling, or soreness of the tongue
• Restlessness
• Stopping of menstrual bleeding
• Tunnel vision
• Weight changes
• Welts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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