Regorafenib (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bleeding gums
• Blurred vision
• Cough or hoarseness
• Coughing up blood
• Difficulty with breathing or swallowing
• Dizziness
• Fever or chills
• Headache
• Increased menstrual flow or vaginal bleeding
• Lower back or side pain
• Nervousness
• Nosebleeds
• Painful or difficult urination
• Pounding in the ears
• Prolonged bleeding from cuts
• Rash
• Red or black, tarry stools
• Redness, swelling, or pain of the skin
• Scaling of the skin on the hands and feet
• Shortness of breath
• Slow or fast heartbeats
• Tingling of the hands and feet
• Ulcers on the skin

• Chest pain or discomfort
• Dark-colored urine
• General feeling of tiredness or weakness
• Light-colored stools
• Nausea or vomiting
• Pain or discomfort in the arms, jaw, back, or neck
• Shakiness in the legs, arms, hands, or feet
• Stomach pain that continues
• Sweating
• Yellow eyes or skin

• Confusion
• Heartburn
• Indigestion
• Severe abdominal pain, cramping, or burning
• Vomiting of material that looks like coffee grounds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Bad, unusual, or unpleasant taste
• Hair loss or thinning of hair
• Lack or loss of strength
• Muscle or joint stiffness
• Weight loss

• Constipation
• Depressed mood
• Dry skin and hair
• Feeling cold
• Muscle cramps
• Weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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