Tofacitinib (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Bladder pain
• Bloody or cloudy urine
• Blurred vision
• Body aches or pain
• Chills
• Cough
• Difficult, burning, or painful urination
• Difficulty breathing
• Dizziness
• Ear congestion
• Fever
• Frequent urge to urinate
• Headache
• Loss of voice
• Lower back or side pain
• Muscle aches
• Nervousness
• Pounding in the ears
• Slow or fast heartbeat
• Sneezing
• Sore throat
• Stuffy or runny nose
• Unusual tiredness or weakness

• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Confusion
• Dark urine
• Decreased urination
• Difficult or labored breathing
• Dry mouth
• Fainting
• Increase in heart rate
• Light-colored stools
• Lightheadedness
• Nausea and vomiting
• Pale skin
• Rapid breathing
• Rapid weight gain
• Shortness of breath
• Sunken eyes
• Thirst
• Tightness in the chest
• Tingling of the hands or feet
• Troubled breathing with exertion
• Unusual bleeding or bruising
• Unusual weight gain or loss
• Upper right abdominal or stomach pain
• Wrinkled skin
• Yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Diarrhea
• Headache

• Acid or sour stomach
• Belching
• Burning feeling in the chest or stomach
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• Difficulty with moving
• Flushing or redness of the skin
• Heartburn
• Indigestion
• Itching skin
• Muscle pain or stiffness
• Pain in the joints
• Rash
• Stomach discomfort, upset, or pain
• Tenderness in the stomach area
• Trouble sleeping
• Unusually warm skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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