Perampanel (Oral Route)

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Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Aggression or anger
• Anxiety
• Clumsiness or unsteadiness
• Dry mouth
• Hyperventilation
• Irregular heartbeats
• Irritability
• Restlessness
• Shakiness and unsteady walk
• Shortness of breath
• Sleepiness or unusual drowsiness
• Trouble sleeping
• Unsteadiness, trembling, or other problems with muscle control or coordination
• Unusual tiredness or weakness

• Abnormal or decreased touch sensation
• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

• Changes in behavior
• Depression
• Thoughts of killing oneself

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Dizziness or lightheadedness
• Feeling of constant movement of self or surroundings
• Headache
• Nausea
• Sensation of spinning

• Back pain
• Bloating or swelling of the face, arms, hands, lower legs, or feet
• Blurred vision
• Body aches or pain
• Bone pain
• Changes in speech patterns
• Chills
• Confusion
• Cough
• Decreased urine output
• Difficulty having a bowel movement (stool)
• Difficulty with breathing
• Difficulty with moving
• Double vision
• Ear congestion
• Fast or irregular heartbeat
• Fever
• Increased thirst
• Lack or loss of strength
• Loss of voice
• Muscle pain or cramps
• Muscle stiffness
• Nasal congestion
• Nausea or vomiting
• Pain in the arms or legs
• Pain in the joints
• Runny nose
• Slurred speech
• Sneezing
• Sore throat
• Trouble with speaking
• Trouble remembering
• Unusual weight gain or loss
• Unusually deep sleep

• Unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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