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Causes
By Mayo Clinic staffDoctors don't know what causes Dupuytren's contracture. Some researchers have speculated that it may be associated with an autoimmune reaction, where a person's immune system attacks its own body tissues. Dupuytren's often occurs in concert with conditions that cause contractures in other parts of the body, such as the feet (Ledderhose disease) or penis (Peyronie's disease).
- Calandruccio JH. Dupuytren contracture. In: Canale ST, et al. Campbell's Operative Orthopaedics. 11th ed. Philadelphia, Pa.: Mosby Elsevier; 2007. http://www.mdconsult.com/das/book/body/185412162-4/958195331/1584/560.html#4-u1.0-B978-0-323-03329-9..50075-1_3999. Accessed Feb. 24, 2010.
- Sheon RP, et al. Dupuytren's contracture. http://www.uptodate.com/home/index.html. Accessed Feb. 24, 2010.
- Stretanski MF. Dupuytren contracture. In: Frontera WR, et al. Essentials of Physical Medicine and Rehabilitation. 2nd ed. Philadelphia, Pa.: Saunders Elsevier; 2008. http://www.mdconsult.com/das/book/body/185680318-3/958880137/1678/28.html#4-u1.0-B978-1-4160-4007-1..50027-4_405. Accessed Feb. 25, 2010.
- Dupuytren's contracture. American Academy of Orthopaedic Surgeons. http://orthoinfo.aaos.org/topic.cfm?topic=a00008. Accessed Feb. 24, 2010.
- Rayan GM. Nonoperative treatment of Dupuytren's disease. Journal of Hand Surgery. 2008;33A:1208.
- Amadio PC (expert opinion). Mayo Clinic, Rochester, Minn. March 8, 2010.
- Hurst LC, et al. Injectable collagenase clostridium histolyticum for Dupuytren's contracture. New England Journal of Medicine. 2009;361:968.
- Xiaflex (prescribing information). Malvern, Pa.: Auxilium Pharmaceuticals, Inc.; 2010. http://www.xiaflex.com/XIAFLEX_prescribing_info.jsp. Accessed March 15, 2010.
- Mercier LR. Dupuytren's contracture. In: Ferri FF. Ferri's Clinical Advisor 2010. Philadelphia, Pa.: Mosby Elsevier; 2009. http://www.mdconsult.com/das/book/body/186345095-3/960507000/2088/198.html#4-u1.0-B978-0-323-05609-0..00013-7--sc0110_4003. Accessed Feb. 25, 2010.
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