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Risk factors
By Mayo Clinic staffA number of factors are believed to increase your risk of the disease, including:
- Age. Dupuytren's contracture occurs most commonly after the age of 50.
- Sex. Men are more likely to develop Dupuytren's and to have more severe contractures than are women.
- Ancestry. People of Northern European descent are at higher risk of the disease.
- Family history. Dupuytren's contracture often runs in families.
- Tobacco and alcohol use. Smoking is associated with an increased risk of Dupuytren's contracture, perhaps because of microscopic changes within blood vessels caused by smoking. Alcohol intake also is associated with Dupuytren's.
- Diabetes. People with diabetes are reported to have an increased risk of Dupuytren's contracture.
References
- Calandruccio JH. Dupuytren contracture. In: Canale ST, et al. Campbell's Operative Orthopaedics. 11th ed. Philadelphia, Pa.: Mosby Elsevier; 2007. http://www.mdconsult.com/das/book/body/185412162-4/958195331/1584/560.html#4-u1.0-B978-0-323-03329-9..50075-1_3999. Accessed Feb. 24, 2010.
- Sheon RP, et al. Dupuytren's contracture. http://www.uptodate.com/home/index.html. Accessed Feb. 24, 2010.
- Stretanski MF. Dupuytren contracture. In: Frontera WR, et al. Essentials of Physical Medicine and Rehabilitation. 2nd ed. Philadelphia, Pa.: Saunders Elsevier; 2008. http://www.mdconsult.com/das/book/body/185680318-3/958880137/1678/28.html#4-u1.0-B978-1-4160-4007-1..50027-4_405. Accessed Feb. 25, 2010.
- Dupuytren's contracture. American Academy of Orthopaedic Surgeons. http://orthoinfo.aaos.org/topic.cfm?topic=a00008. Accessed Feb. 24, 2010.
- Rayan GM. Nonoperative treatment of Dupuytren's disease. Journal of Hand Surgery. 2008;33A:1208.
- Amadio PC (expert opinion). Mayo Clinic, Rochester, Minn. March 8, 2010.
- Hurst LC, et al. Injectable collagenase clostridium histolyticum for Dupuytren's contracture. New England Journal of Medicine. 2009;361:968.
- Xiaflex (prescribing information). Malvern, Pa.: Auxilium Pharmaceuticals, Inc.; 2010. http://www.xiaflex.com/XIAFLEX_prescribing_info.jsp. Accessed March 15, 2010.
- Mercier LR. Dupuytren's contracture. In: Ferri FF. Ferri's Clinical Advisor 2010. Philadelphia, Pa.: Mosby Elsevier; 2009. http://www.mdconsult.com/das/book/body/186345095-3/960507000/2088/198.html#4-u1.0-B978-0-323-05609-0..00013-7--sc0110_4003. Accessed Feb. 25, 2010.
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