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By Mayo Clinic staffIn most cases, your doctor can diagnose dyshidrosis based on a physical exam.
Occasionally, a skin biopsy is necessary to confirm the diagnosis or to rule out another cause. In this test, your doctor removes a small sample of the affected skin. The skin sample is examined under a microscope to confirm a diagnosis of dyshidrosis.
Your doctor may also recommend a procedure called a KOH test to rule out other causes, such as a fungal infection. To perform a KOH test, your doctor scrapes your skin with a glass slide to collect dead skin cells. The skin cells are mixed with potassium hydroxide (KOH) and viewed under a microscope to help single out a fungal infection.
If an allergy is suspected to cause dyshidrosis, a patch test (contact hypersensitivity allergy test) may help determine a possible cause. During a patch test, potential allergens are applied to a patch, which is then placed on your skin to check for a reaction.