Mayo Clinic Health Manager

Get free personalized health guidance for you and your family.

Get Started

Free

E-Newsletter

Subscribe to receive the latest updates on health topics. About our newsletters

  • Housecall
  • Alzheimer's caregiving
  • Living with cancer

Causes

By Mayo Clinic staff

It's not known specifically what causes dysthymia. Researchers believe that dysthymia has similar origins as depression, including:

  • Biochemical. Some evidence from imaging studies indicates that people with depression have physical changes in their brains, and this may be true of dysthymia, too. The significance of these changes is still uncertain but may eventually help pinpoint causes. The naturally occurring brain chemicals called neurotransmitters, which are linked to mood, also may play a role in causing dysthymia.
  • Genes. Some studies show that depression is more common in people whose biological family members also have the condition, and this also appears to be the case with dysthymia. Researchers are trying to find genes that may contribute to causing dysthymia.
  • Environment. Again, as with depression, environment may contribute to dysthymia. Environmental causes are situations in your life that are difficult to cope with, such as the loss of a loved one, financial problems and high stress.

DS01111

Aug. 26, 2008

© 1998-2009 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Reliable tools for healthier lives," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

Print Share Reprints

Text Size: smaller largerlarger