Mayo Clinic Health Manager
Get free personalized health guidance for you and your family.
Get StartedCauses
By Mayo Clinic staffMany diseases and conditions can contribute to elevated liver enzymes. Your doctor determines the specific cause of your elevated liver enzymes by reviewing your medications, your signs and symptoms and, in some cases, other tests and procedures.
More common causes of elevated liver enzymes include:
- Certain prescription medications, including statin drugs used to control cholesterol
- Hepatitis A
- Hepatitis B
- Hepatitis C
- Nonalcoholic fatty liver disease
- Obesity
- Over-the-counter pain medications, including acetaminophen (Tylenol, others)
Other causes of elevated liver enzymes may include:
- Alcoholic hepatitis
- Autoimmune hepatitis
- Celiac disease
- Cirrhosis
- Cytomegalovirus (CMV) infection
- Dermatomyositis
- Epstein-Barr virus
- Gallbladder inflammation (cholecystitis)
- Heart attack
- Hemochromatosis
- Hypothyroidism (underactive thyroid)
- Liver cancer
- Mononucleosis
- Muscular dystrophy
- Pancreatitis
- Polymyositis
- Toxic hepatitis
- Wilson's disease
Causes shown here are commonly associated with this symptom. Work with your doctor or other health care professional for an accurate diagnosis.