Elevated liver enzymesBy Mayo Clinic staff
Original Article: http://www.mayoclinic.com/health/elevated-liver-enzymes/MY00508
Elevated liver enzymes may indicate inflammation or damage to cells in the liver. Inflamed or injured liver cells leak higher than normal amounts of certain chemicals, including liver enzymes, into the bloodstream, which can result in elevated liver enzymes on blood tests.
The specific elevated liver enzymes most commonly found are:
- Alanine transaminase (ALT)
- Aspartate transaminase (AST)
Elevated liver enzymes may be discovered during routine blood testing. In most cases, liver enzyme levels are only mildly and temporarily elevated. Most of the time, elevated liver enzymes don't signal a chronic, serious liver problem.
Many diseases and conditions can contribute to elevated liver enzymes. Your doctor determines the specific cause of your elevated liver enzymes by reviewing your medications, your signs and symptoms and, in some cases, other tests and procedures.
More common causes of elevated liver enzymes include:
Other causes of elevated liver enzymes may include:
- Alcoholic hepatitis
- Autoimmune hepatitis
- Celiac disease
- Cytomegalovirus (CMV) infection
- Epstein-Barr virus
- Gallbladder inflammation (cholecystitis)
- Heart attack
- Hypothyroidism (underactive thyroid)
- Liver cancer
- Muscular dystrophy
- Toxic hepatitis
- Wilson's disease
When to see a doctor
If a liver function test reveals you have elevated liver enzymes, ask your doctor about what your test results might mean. Your doctor may suggest you undergo other tests and procedures to determine what's causing your elevated liver enzymes.
- Ferri FF. Ferri's Clinical Advisor 2011: Instant Diagnosis and Treatment. Philadelphia, Pa.: Mosby Elsevier; 2011. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-0-323-05610-6..C2009-0-38600-6--TOP&isbn=978-0-323-05610-6&about=true&uniqId=230100505-53. Accessed March 11, 2011.
- Pratt DS. Liver chemistry and function tests. In: Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&isbn=978-1-4160-6189-2&about=true&uniqId=229935664-2192. Accessed March 11, 2011.
- Wilkinson JM (expert opinion). Mayo Clinic, Rochester, Minn. April 13, 2011.
- Green RM, et al. AGA technical review on the evaluation of liver chemistry tests. Gastroenterology. 2002;123:1367.
- Peterson DM (expert opinion). Mayo Clinic, Scottsdale/Phoenix, Ariz. April 14, 2011.