DefinitionBy Mayo Clinic staff
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Emphysema occurs when the air sacs in your lungs are gradually destroyed, making you progressively more short of breath. Emphysema is one of several diseases known collectively as chronic obstructive pulmonary disease (COPD). Smoking is the leading cause of emphysema.
As it worsens, emphysema turns the spherical air sacs — clustered like bunches of grapes — into large, irregular pockets with gaping holes in their inner walls. This reduces the surface area of the lungs and, in turn, the amount of oxygen that reaches your bloodstream.
Emphysema also slowly destroys the elastic fibers that hold open the small airways leading to the air sacs. This allows these airways to collapse when you breathe out, so the air in your lungs can't escape. Treatment may slow the progression of emphysema, but it can't reverse the damage.
- Shapiro SD, et al. Chronic bronchitis and emphysema. In: Mason RJ, et al. Murray and Nadel's Textbook of Respiratory Medicine. 5th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/das/book/body/192068760-2/0/1288/0.html. Accessed Feb. 24, 2011.
- What is COPD? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/Copd/Copd_WhatIs.html. Accessed Feb. 24, 2011.
- Anthonisen N. Chronic obstructive pulmonary disease. In: Goldman L, et al. Cecil Medicine. 23rd ed. Philadelphia, Pa.: Saunders Elsevier; 2008. http://www.mdconsult.com/das/book/body/191371208-2/0/1492/0.html#. Accessed Feb. 24, 2011.
- Chronic obstructive pulmonary disease. In: Ferri FF. Ferri's Clinical Advisor 2011: Instant Diagnosis and Treatment. Philadelphia, Pa.: Mosby Elsevier; 2011. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-0-323-05610-6..C2009-0-38600-6--TOP&isbn=978-0-323-05610-6&about=true&uniqId=230100505-53. Accessed Feb. 24, 2011.
- Rennard SI. Chronic obstructive pulmonary disease: Definition, clinical manifestations, diagnosis and staging. http://www.uptodate.com/home/index.html. Accessed Feb. 24, 2011.
- Rennard SI. Management of chronic obstructive pulmonary disease. http://www.uptodate.com/home/index.html. Accessed Feb. 25, 2011.
- Pulmonary rehabilitation: A team approach to improving quality of life. American College of Chest Physicians. http://www.chestnet.org/accp/patient-guides/pulmonary-rehabilitation-team-approach-improving-quality-life. Accessed Feb. 25, 2011.
- What is oxygen therapy? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/oxt/oxt_all.html. Accessed Feb. 25, 2011.