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Causes
By Mayo Clinic staffHealthy cells grow and divide in an orderly way to keep your body functioning normally. But sometimes cells become abnormal (mutate) and grow out of control. The cells continue dividing even when new cells aren't needed. These abnormal cells can invade and destroy nearby tissues and even have the ability to travel to other parts of the body and begin growing there.
In endometrial cancer, cancer cells develop in the lining of the uterus. Why these cancer cells develop isn't entirely known. However, scientists believe that estrogen levels play a role in the development of endometrial cancer. Factors that can increase the levels of this hormone and other risk factors for the disease have been identified and continue to emerge. In addition, ongoing research is devoted to studying changes in certain genes that may cause the cells in the endometrium to become cancerous.
- Detailed guide: Endometrial cancer. American Cancer Society. http://documents.cancer.org/140.00/140.00.pdf. Accessed Sept. 9, 2008.
- Endometrial cancer treatment (PDQ). National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/endometrial/patient/allpages/print. Accessed Sept. 16, 2008.
- Bakkum-Gamez JN, et al. Current issues in the management of endometrial cancer. Mayo Clinic Proceedings. 2008;83(1):97-112.
- Sorosky JI. Endometrial cancer. Obstetrics and Gynecology. 2008;111(2, Part 1):436-447.
- Moynihan T (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 21, 2008.
