DefinitionBy Mayo Clinic staff
Endometriosis (en-doe-me-tree-O-sis) is an often painful disorder in which tissue that normally lines the inside of your uterus — the endometrium — grows outside your uterus (endometrial implant). Endometriosis most commonly involves your ovaries, bowel or the tissue lining your pelvis. Rarely, endometrial tissue may spread beyond your pelvic region.
In endometriosis, displaced endometrial tissue continues to act as it normally would — it thickens, breaks down and bleeds with each menstrual cycle. Because this displaced tissue has no way to exit your body, it becomes trapped. When endometriosis involves the ovaries, cysts called endometriomas may form. Surrounding tissue can become irritated, eventually developing scar tissue and adhesions — abnormal tissue that binds organs together.
Endometriosis can cause pain — sometimes severe — especially during your period. Fertility problems also may develop. Fortunately, effective treatments are available.
- Endometriosis. The National Women's Health Information Center. http://www.womenshealth.gov/publications/our-publications/fact-sheet/endometriosis.html. Accessed March 5, 2013.
- Schenken RS. Pathogenesis, clinical features, and diagnosis of endometriosis. http://www.uptodate.com/home. Accessed March 5, 2013.
- Frequently asked questions. Gynecological problems FAQ013. Endometriosis. American College of Obstetricians and Gynecologists. http://www.acog.org/~/media/For%20Patients/faq013.pdf?dmc=1&ts=20130305T1348596508. Accessed March 5, 2013.
- Pain management of endometriosis. American College of Obstetricians and Gynecologists. http://www.acog.org/About_ACOG/News_Room/News_Releases/2010/Pain_Management_of_Endometriosis. Accessed March 5, 2013.
- American College of Obstetricians and Gynecologists (ACOG) Committee on Practice Bulletins — Obstetrics. ACOG Practice Bulletin No. 114: Management of endometriosis. Obstetrics & Gynecology. 2010;116:223.
- What is assisted reproductive technology? Centers for Disease Control and Prevention. http://www.cdc.gov/art/index.htm. Accessed March 5, 2013.
- Schenken RS. Overview of the treatment of endometriosis. http://www.uptodate.com/home. Accessed March 5, 2013.
- Schrager S, et al. Evaluation and treatment of endometriosis. American Family Physician. 2012;87:107.
- Pearce CL, et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: A pooled analysis of case-control studies. The Lancet Oncology. 2012;13:385.
- Gallenberg MM (expert opinion). Mayo Clinic, Rochester, Minn. March 8, 2013.
- Bakkum-Gamez JN (expert opinion). Mayo Clinic, Rochester, Minn. March 13, 2013.