Treatments and drugsBy Mayo Clinic staff
Epididymitis caused by a sexually transmitted infection (STI) or other infection is treated with antibiotic medications. Your sexual partner will also need treatment. Make sure your doctor is aware of any other medications you're taking or any allergies you have. This information, as well as determining what type of infection you have, will help your doctor select the best treatment.
Be sure to take the entire course of antibiotics prescribed by your doctor, even though you may feel better in one to three days after you start treatment. If you're not feeling better in that time, contact your doctor.
When you've finished your medication, it's a good idea to return to your doctor for a follow-up visit to be sure that the infection has cleared up. If it hasn't, your doctor may try another antibiotic. If the infection still doesn't clear, your doctor may do further tests to determine whether your epididymitis is caused by something other than a bacterial infection or an STI.
If a pocket of pus (abscess) has formed, it may need to be drained, and in some cases part or all of the epididymis needs to be removed surgically (epididymectomy). Surgery may also be considered if epididymitis is due to underlying physical defects, but many people continue to have scrotal pain following epididymectomy.
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