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Causes
By Mayo Clinic staffIt's not clear what causes esophageal cancer. Esophageal cancer occurs when cells in your esophagus develop errors (mutations) in their DNA. The errors make cells grow and divide out of control. The accumulating abnormal cells form a tumor in the esophagus that can grow to invade nearby structures and spread to other parts of the body.
Types of esophageal cancer
Esophageal cancer is classified according to the type of cells that are involved. The type of esophageal cancer you have helps determine your treatment options. Types of esophageal cancer include:
- Adenocarcinoma. Adenocarcinoma begins in the cells of mucus-secreting glands in the esophagus. Adenocarcinoma occurs most often in the lower portion of the esophagus. Adenocarcinoma is the most common form of esophageal cancer in the United States, and it affects primarily white men.
- Squamous cell carcinoma. The squamous cells are flat, thin cells that line the surface of the esophagus. Squamous cell carcinoma occurs most often in the middle of the esophagus. Squamous cell carcinoma is the most prevalent esophageal cancer worldwide.
- Other rare types. Rare forms of esophageal cancer include choriocarcinoma, lymphoma, melanoma, sarcoma and small cell cancer.
References
- Swanson S. Surgical management of localized esophageal cancer. http://www.uptodate.com/home/index.html. Accessed March 3, 2011.
- Esophageal cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/PDF/esophageal.pdf. Accessed March 4, 2011.
- Esophageal cancer treatment (PDQ) health professional version. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/esophageal/healthprofessional/allpages. Accessed March 4, 2011.
- Esophageal cancer screening (PDQ) health professional version. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/screening/esophageal/healthprofessional/allpages. Accessed March 4, 2011.
- Eating hints for cancer patients: Before, during and after treatment. National Cancer Institute. http://www.cancer.gov/cancertopics/coping/eatinghints. Accessed March 4, 2011.
- Lagergren J, et al. Oesophageal cancer. British Medical Journal. 2010;341:1207.
- Management of esophageal cancer. Current Problems in Surgery. 2010;47:845.
- NCCN guidelines: Esophageal and esophagogastric junction cancers. National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed March 4, 2011.
- Gan S, et al. Advances in clinical practice: New endoscopic and surgical treatment options for early esophageal adenocarcinoma. Journal of Gastroenterology and Hepatology. 2010;50:1478.
- Campbell NP, et al. World Journal of Gastroenterology. Neoadjuvant treatment of esophageal cancer. 2010;16:3793.
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