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Definition
By Mayo Clinic staffFactor V Leiden (FAK-tur five LIDE-n) is a common inherited genetic disorder that can increase your chance of developing abnormal blood clots (thrombophilia), usually in your veins.
Most people with factor V Leiden never develop abnormal clots. However, some people with factor V Leiden develop clots that lead to long-term health problems or become life-threatening.
Both men and women can have factor V Leiden, but women may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen.
If you have factor V Leiden and have developed blood clots, medications can lessen your risk of developing additional blood clots and help you avoid potentially serious complications.
- Learning about factor v Leiden thrombophilia. National Human Genome Research Institute. http://www.genome.gov/pfv.cfm?pageID=15015167. Accessed May 21, 2010.
- Ornstein DL, et al. Factor V Leiden. Circulation. 2003;107:e94.
- Deep vein thrombosis. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec07/ch081/ch081b.html. Accessed May 21, 2010.
- Pulmonary embolism. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec05/ch050/ch050a.html. Accessed May 21, 2010.
- Laubach J, et al. Hematological changes of pregnancy. In: Hoffman R, et al. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2008. http://www.mdconsult.com/book/player/book.do?method=display&type=aboutPage&decorator=header&eid=4-u1.0-B978-0-443-06715-0..X5001-8--TOP&isbn=978-0-443-06715-0&uniq=203749156. Accessed May 21, 2010.
- Konkle BA, et al. Hemostasis, thrombosis, fibrinolysis, and cardiovascular disease. In: Libby P, et al. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/book/player/book.do?method=display&type=aboutPage&decorator=header&eid=4-u1.0-B978-1-4160-4106-1..X5001-8--TOP&isbn=978-1-4160-4106-1&uniq=203749156. Accessed May 21, 2010.
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