Fibrous dysplasia


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Definition

By Mayo Clinic staff

Fibrous dysplasia is a bone disorder in which scar-like (fibrous) tissue develops in place of normal bone. As the bone grows, the softer, fibrous tissue expands, weakening the bone. Fibrous dysplasia can cause the affected bone to deform and become susceptible to fracture.

Most people with fibrous dysplasia are diagnosed during adolescence or early adulthood. Mild cases usually cause no signs or symptoms. More-serious cases of fibrous dysplasia may result in bone pain and deformity.

The basic cause of fibrous dysplasia is unknown. There's no cure for fibrous dysplasia. Treatment focuses on relieving signs and symptoms.

Symptoms
References
  1. Fibrous dysplasia. American Academy of Orthopaedic Surgeons. http://orthoinfo.aaos.org/topic.cfm?topic=A00083. Accessed June 3, 2011.
  2. Tis JE. Overview of benign bone tumors in children and adolescents. http://www.uptodate.com/home/index.html. Accessed June 3, 2011.
  3. Whyte MP. Osteonecrosis, osteosclerosis/hyperostosis, and other disorders of bone. In: Goldman L, et al. Cecil Medicine. 23rd ed. Philadelphia, Pa.: Saunders Elsevier; 2008. http://www.mdconsult.com/das/book/body/191371208-2/0/1492/0.html#. Accessed June 3, 2011.
  4. Rosenberg AE. Bones, joints and soft-tissue tumors. In: Kumar V, et al. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-0792-2..50031-6--cesec46&isbn=978-1-4377-0792-2&sid=1166563817&uniqId=255806599-7#4-u1.0-B978-1-4377-0792-2..50031-6--cesec64. Accessed June 3, 2011.
  5. Chapurlat RD, et al. Treatment of fibrous dysplasia of bone with intravenous pamidronate: long-term effectiveness and evaluation of predictors of response to treatment. Bone. 2004;35:235.
  6. Joglekar SB (expert opinion). Mayo Clinic, Rochester, Minn. June 18, 2011.
  7. Sim FH (expert opinion). Mayo Clinic, Rochester, Minn. June 18, 2011.
DS00991 July 7, 2011

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