Cholecystectomy (gallbladder removal)

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  • With Mayo Clinic gastroenterologist

    Michael F. Picco, M.D.

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Question

Chronic diarrhea: A concern after gallbladder removal?

I had my gallbladder removed six months ago, and I continue to have diarrhea. Is this unusual? What can I do about it?

Answer

from Michael F. Picco, M.D.

It's not clear how many people develop the frequent loose, watery stools that characterize diarrhea after surgery to remove their gallbladders (cholecystectomy). Studies have found as few as 1 in 100 people undergoing gallbladder surgery or as many as 1 in 3 develops diarrhea. In most cases, the diarrhea resolves soon after the surgery. Rarely, it may last for years.

The cause of diarrhea after gallbladder removal isn't clear. Some experts believe that it results from an increase in bile, especially bile acids, entering the large intestine — which may act as a laxative.

Treatments you and your doctor may consider for controlling your diarrhea after cholecystectomy include:

  • Anti-diarrheal medications, such as loperamide (Imodium A-D)
  • Medications that impair absorption of bile acids, such as cholestyramine or aluminum hydroxide

Talk to your doctor about your options. You may also consider limiting foods that can worsen diarrhea in general, including:

  • Caffeine
  • Dairy products
  • Greasy foods
  • Very sweet foods
Next question
Can you recommend a diet after gallbladder removal?
References
  1. Fisher M, et al. Diarrhoea after laparoscopic cholecystectomy: Incidence and main determinants. ANZ Journal of Surgery. 2008;78:482.
  2. Fort JM, et al. Bowel habit after cholecystectomy: Physiological changes and clinical implications. Gastroenterology. 1996;111:617.
  3. Ros E, et al. Postcholecystectomy symptoms: A prospective study of gallstone patients before and two years after surgery. Gut. 1987;28:1500.
  4. Sauter GH, et al. Bowel habits and bile acid malabsorption in the months after cholecystectomy. The American Journal of Gastroenterology. 2002;97:1732.
  5. Hearing SD, et al. Effect of cholecystectomy on bowel function: A prospective, controlled study. Gut. 1999;45:889.
  6. Phillips SF. Diarrhea after cholecystectomy: If so, why? Gastroenterology. 1996;111:816.
  7. Hutcheon DF, et al. Postcholecystectomy diarrhea. JAMA. 1979;24:823.
  8. Arlow FL, et al. Bile acid-mediated postcholecystectomy diarrhea. Archives of Internal Medicine. 1987;147:1327.
  9. Diarrhea. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/diarrhea/index.htm. Accessed March. 8, 2011.
AN00067 March 23, 2011

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